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Low-grade UTUC Treated With Nadofaragene Firadenovec Administered to Renal Pelvis
NCT06668493 · View on ClinicalTrials.gov ↗
Study Summary
The primary purpose of this trial is to evaluate the safety \& tolerability of Nadofaragene Firadenovec in subjects with LG-UTUC. To help with this evaluation, a safety lead-in period will be conducted for the first 6 subjects. Complete response is at 3 or 6 months defined as absence of any UTUC in the renal pelvis.
Conditions Studied
Interventions
- DRUG Nadofaragene Firadenovec
Study Locations (7)
Arizona
- Mayo Clinic - Scottsdale Arizona — Scottsdale
Florida
- Mayo Clinic — Jacksonville
Indiana
- Indiana University — Indianapolis
Minnesota
- Mayo Clinic - Rochester Minnesota — Rochester
New York
- Memorial Sloan Kettering Cancer Center — New York
Pennsylvania
- University of Pennsylvania - Perelman Center for Advanced Medicine - Penn Urology — Philadelphia
Texas
- MD Anderson Cancer Center - Genitourinary (GU) Cancer Center — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2025-06-12 |
| Est. Completion | 2029-11-30 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06668493
The ClinicalTrials.gov registry entry for NCT06668493 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Ferring Pharmaceuticals, which has 27 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Low-grade Upper Tract Urothelial Carcinoma appearing as the primary indexed condition, and to 1 intervention — of which Nadofaragene Firadenovec is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06668493 reports 7 study locations spanning 7 distinct geographic areas — top geographies include Arizona, Florida, Indiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06668493 about?
NCT06668493 is a clinical study titled "Low-grade UTUC Treated With Nadofaragene Firadenovec Administered to Renal Pelvis". The primary purpose of this trial is to evaluate the safety \& tolerability of Nadofaragene Firadenovec in subjects with LG-UTUC. To help with this evaluation, a safety lead-in period will be conducted for the first 6 subjects. Complete response is at 3 or 6 months defined as absence of any UTUC in ...
What is the current status of trial NCT06668493?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2025-06-12. Estimated completion is 2029-11-30.
What conditions does trial NCT06668493 study?
This clinical trial studies the following conditions: Low-grade Upper Tract Urothelial Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06668493?
The interventions under investigation include: Nadofaragene Firadenovec (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06668493?
This trial is sponsored by Ferring Pharmaceuticals, which has 27 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06668493 being conducted?
This trial has 7 study locations across Arizona, Florida, Indiana, Minnesota, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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