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NCT06662786 · ClinicalTrials.gov registry record · Phase 3
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
A Phase 3 study of Colorectal Neoplasms, sponsored by Janssen Research & Development.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 1,000
- Enrollment target
- 20
- Study locations
NCT06662786 is a Phase 3 study of Colorectal Neoplasms that is actively recruiting participants, run by Janssen Research & Development. The registered enrollment target is 1,000 participants, above the 558-participant average among 54 other Colorectal Neoplasms trials with a reported enrollment target (79% higher). The trial reports 20 study locations across 9 states.
The verdict
NCT06662786, a Phase 3 study of Colorectal Neoplasms, is actively recruiting participants, sponsored by Janssen Research & Development.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 1,000 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, oxaliplatin (mFOLFOX6) or 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus cetuximab and mFOLFOX6 or FOLFIRI in adult participants with Kirsten rat sarcoma viral oncogene homolog (KRAS)/ Neuroblastoma RAS viral oncogene homolog (NRAS) and v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) wild type (WT) unresectable or metastatic left-sided colorectal cancer.
Conditions Studied
Interventions
- BIOLOGICAL Cetuximab
- DRUG Oxaliplatin
- BIOLOGICAL Amivantamab
- DRUG 5-fluorouracil
- DRUG Leucovorin calcium/Levoleucovorin
Study Locations (20)
California
- CBCC Global Research - Bakersfield
- Los Angeles Cancer Network - Glendale
- Cancer and Blood Specialty Clinic - Los Alamitos
- USC Norris Comprehensive Cancer Center - Los Angeles
- UCLA - Santa Monica
- Providence Medical Foundation - Santa Rosa
- Torrance Memorial Physicians Network - Torrance
Florida
- Florida Cancer Specialists South - Fort Myers
- AdventHealth Medical Group Oncology and Hematology at Orlando - Orlando
- Florida Cancer Specialists North Region - St. Petersburg
- Florida Cancer Specialists East - West Palm Beach
Arkansas
- St. Bernard's Medical Center - Jonesboro
- Highlands Oncology Group - Springdale
Georgia
- Grady Memorial Hospital - Atlanta
- Winship Cancer Institute Emory University - Atlanta
Arizona
- Banner MD Anderson Cancer Center - Gilbert
Colorado
- Rocky Mountain Cancer Centers - Denver
Connecticut
- Yale University School Of Medicine - New Haven
District of Columbia
- Georgetown Univ Medical Center Lombardi Cancer Center - Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,000 participants |
| Start Date | 2024-10-18 |
| Est. Completion | 2032-01-30 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06662786
The ClinicalTrials.gov registry entry for NCT06662786 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 1,000 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 558-participant average among 54 other Colorectal Neoplasms trials with a reported enrollment target (79% higher). The listed sponsor is Janssen Research & Development, which has 593 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Colorectal Neoplasms appearing as the primary indexed condition, and to 5 interventions - of which Cetuximab is the first listed.
NCT06662786 reports 20 study locations spanning 9 distinct geographic areas - top geographies include California, Florida, Arkansas.
Frequently Asked Questions
What is clinical trial NCT06662786 about?
NCT06662786 is a clinical study titled "A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer". The purpose of this study is to compare how long the participants are disease-free (progression-free survival) when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, oxaliplatin (mFOLFOX6) or 5-fluorouracil, leucovorin calcium (folini...
What is the current status of trial NCT06662786?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 1,000 participants. The study started on 2024-10-18. Estimated completion is 2032-01-30.
What conditions does trial NCT06662786 study?
This clinical trial studies the following conditions: Colorectal Neoplasms.
What interventions are being tested in trial NCT06662786?
The interventions under investigation include: Cetuximab (BIOLOGICAL), Oxaliplatin (DRUG), Amivantamab (BIOLOGICAL), 5-fluorouracil (DRUG), Leucovorin calcium/Levoleucovorin (DRUG).
Who is sponsoring clinical trial NCT06662786?
This trial is sponsored by Janssen Research & Development, which has 593 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06662786 being conducted?
This trial has 20 study locations across Arizona, Arkansas, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.