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A Phase 2 Study of CRD-4730 in CPVT
NCT06658899 · View on ClinicalTrials.gov ↗
Study Summary
This is a Phase 2, multicenter, double-blind, sponsor blinded, placebo-controlled, repeat-dose clinical study of CRD-4730 to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of CRD-4730 to participants with Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT). Participants with CPVT will complete a 3-period, randomized 3-sequence study. Each participant will be randomized to one of the 3 sequences in which they will receive 2 different doses of CRD-4730 and 1 dose of matching placebo.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG CRD-4730
Study Locations (9)
California
- Cardurion Investigative Site — San Francisco
North Carolina
- Cardurion Investigative Site — Morrisville
Texas
- Cardurion Investigative Site — Houston
Wisconsin
- Cardurion Investigative Site — Madison
British Columbia
- Cardurion Investigative Site — Vancouver
Other
- Cardurion Investigative Site — Saint-Herblain
Pavia
- Cardurion Investigative Site — Pavia
North Holland
- Cardurion Investigative Site — Amsterdam
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2025-12-01 |
| Est. Completion | 2027-04 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06658899
The ClinicalTrials.gov registry entry for NCT06658899 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Cardurion Pharmaceuticals, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Catecholaminergic Polymorphic Ventricular Tachycardia appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06658899 reports 9 study locations spanning 9 distinct geographic areas — top geographies include California, North Carolina, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06658899 about?
NCT06658899 is a clinical study titled "A Phase 2 Study of CRD-4730 in CPVT". This is a Phase 2, multicenter, double-blind, sponsor blinded, placebo-controlled, repeat-dose clinical study of CRD-4730 to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of CRD-4730 to participants with Catecholaminergic Polymorphic Ventricular Tachycardia (CPV...
What is the current status of trial NCT06658899?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 12 participants. The study started on 2025-12-01. Estimated completion is 2027-04.
What conditions does trial NCT06658899 study?
This clinical trial studies the following conditions: Catecholaminergic Polymorphic Ventricular Tachycardia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06658899?
The interventions under investigation include: Placebo (DRUG), CRD-4730 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06658899?
This trial is sponsored by Cardurion Pharmaceuticals, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06658899 being conducted?
This trial has 9 study locations across California, North Carolina, Texas, Wisconsin, British Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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