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A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease.
NCT06632600 · View on ClinicalTrials.gov ↗
Study Summary
This study is to investigate the ability of LXE408 to clear or reduce the level of parasites in the blood of people with chronic Chagas disease. Participants must have chronic Chagas disease without severe organ dysfunction.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG LXE408
- DRUG Benznidazole
Study Locations (18)
Other
- Novartis Investigative Site — Corrientes
- Novartis Investigative Site — Córdoba
- Novartis Investigative Site — Formosa
- Novartis Investigative Site — Bogotá
- Novartis Investigative Site — Bogotá
- Novartis Investigative Site — Floridablanca
- Novartis Investigative Site — San Gil
Buenos Aires
- Novartis Investigative Site — CABA
- Novartis Investigative Site — CABA
California
- Olive View UCLA Educ and Res Ins — Sylmar
Florida
- University of Florida Shands — Gainesville
Massachusetts
- Boston Medical Center — Boston
Texas
- Baylor College of Medicine — Houston
Minas Gerais
- Novartis Investigative Site — Montes Claros
Rio de Janeiro
- Novartis Investigative Site — Rio de Janeiro
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 130 participants |
| Start Date | 2025-04-28 |
| Est. Completion | 2030-09-21 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06632600
The ClinicalTrials.gov registry entry for NCT06632600 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 130 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novartis Pharmaceuticals, which has 792 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Chagas Disease appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06632600 reports 18 study locations spanning 11 distinct geographic areas — top geographies include Other, Buenos Aires, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06632600 about?
NCT06632600 is a clinical study titled "A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease.". This study is to investigate the ability of LXE408 to clear or reduce the level of parasites in the blood of people with chronic Chagas disease. Participants must have chronic Chagas disease without severe organ dysfunction.
What is the current status of trial NCT06632600?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 130 participants. The study started on 2025-04-28. Estimated completion is 2030-09-21.
What conditions does trial NCT06632600 study?
This clinical trial studies the following conditions: Chagas Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06632600?
The interventions under investigation include: Placebo (DRUG), LXE408 (DRUG), Benznidazole (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06632600?
This trial is sponsored by Novartis Pharmaceuticals, which has 792 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06632600 being conducted?
This trial has 18 study locations across California, Florida, Massachusetts, Texas, Buenos Aires. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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