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ACTIVE NOT RECRUITING Phase 3

Interventional Study of Vosoritide for the Treatment of Children With Hypochondroplasia

NCT06455059 · View on ClinicalTrials.gov ↗

Study Summary

The intent and design of this Phase 3 study is to assess vosoritide as a therapeutic option for the treatment of children with hypochondroplasia (HCH).

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Vosoritide

Study Locations (20)

Other

  • Hospices Civils de Lyon - Hopital Femme Mere Enfant — Lyon
  • Hopital de la Timone — Marseille
  • Hopital Necker-Enfants Malade — Paris
  • CHU de Toulouse — Toulouse
  • Uniklinik Koln — Cologne
  • Univeristatskinderklinik Magdeburg — Magdeburg
  • Instituto Giannina Gaslini — Genoa
  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS — Rome
  • Ospedale Pediatrico Bambino Gesu — Rome
  • Osaka University Hosptial — Osaka
  • Tokushima University Hospital — Tokushima
  • Institute of Science Tokyo Hospital — Tokyo

Delaware

  • Nemours Alfred I. DuPont Hospital for Children — Wilmington

District of Columbia

  • Children's National Medical Center — Washington D.C.

Illinois

  • Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago

Wisconsin

  • Medical College of Wisconsin — Milwaukee

Victoria

  • Murdoch Children's Research Institute — Parkville

Alberta

  • University of Alberta Stollery Children's Hospital — Edmonton

Ontario

  • SickKids - The Hospital for Sick Children — Toronto

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2024-06-17
Est. Completion 2026-08-01
Phase Phase 3

Sponsor

BioMarin Pharmaceutical

31 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06455059

The ClinicalTrials.gov registry entry for NCT06455059 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BioMarin Pharmaceutical, which has 31 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Hypochondroplasia appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06455059 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Other, Delaware, District of Columbia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06455059 about?

NCT06455059 is a clinical study titled "Interventional Study of Vosoritide for the Treatment of Children With Hypochondroplasia". The intent and design of this Phase 3 study is to assess vosoritide as a therapeutic option for the treatment of children with hypochondroplasia (HCH).

What is the current status of trial NCT06455059?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 80 participants. The study started on 2024-06-17. Estimated completion is 2026-08-01.

What conditions does trial NCT06455059 study?

This clinical trial studies the following conditions: Hypochondroplasia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06455059?

The interventions under investigation include: Placebo (DRUG), Vosoritide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06455059?

This trial is sponsored by BioMarin Pharmaceutical, which has 31 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06455059 being conducted?

This trial has 20 study locations across Delaware, District of Columbia, Illinois, Wisconsin, Victoria. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial