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A Study of ARV-393 in Relapsed/Refractory Non-Hodgkin Lymphoma.
NCT06393738 · View on ClinicalTrials.gov ↗
Study Summary
This clinical trial is studying the safety and potential anti-tumor activity of an investigational drug called ARV-393 in patients diagnosed with advanced Relapsed/Refractory non-Hodgkin's lymphoma (R/R NHL) to determine if ARV-393 may be a possible treatment option. ARV-393 is thought to work by breaking down a protein present in many types of non-Hodgkins lymphomas, which may prevent, slow or stop tumor growth. This is the first time ARV-393 will be used by people. The investigational drug will be given as an oral tablet.
Conditions Studied
Interventions
- DRUG Glofitamab
- DRUG ARV-393
Study Locations (17)
Other
- Clinical Trial Site — Copenhagen
- Clinical Trial Site — Odense C
- Clinical Trial Site — Barcelona
- Clinical Trial Site — Madrid
- Clinical Trial Site — Salamanca
New York
- Clinical Trial Site — New York
- Clinical Trial Site — New York
Connecticut
- Clinical Trial Site — New Haven
Michigan
- Clinical Trial Site — Detroit
New Jersey
- Clinical Trial Site — New Brunswick
Ohio
- Clinical Trial Site — Cleveland
Tennessee
- Clinical Trial Site — Nashville
Texas
- Clinical Trial Site — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 255 participants |
| Start Date | 2024-09-05 |
| Est. Completion | 2028-03 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06393738
The ClinicalTrials.gov registry entry for NCT06393738 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 255 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Arvinas, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Relapsed/Refractory (R/R) Mature B Cell Non Hodgkin Lymphoma (NHL) appearing as the primary indexed condition, and to 2 interventions — of which Glofitamab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06393738 reports 17 study locations spanning 12 distinct geographic areas — top geographies include Other, New York, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06393738 about?
NCT06393738 is a clinical study titled "A Study of ARV-393 in Relapsed/Refractory Non-Hodgkin Lymphoma.". This clinical trial is studying the safety and potential anti-tumor activity of an investigational drug called ARV-393 in patients diagnosed with advanced Relapsed/Refractory non-Hodgkin's lymphoma (R/R NHL) to determine if ARV-393 may be a possible treatment option. ARV-393 is thought to work by b...
What is the current status of trial NCT06393738?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 255 participants. The study started on 2024-09-05. Estimated completion is 2028-03.
What conditions does trial NCT06393738 study?
This clinical trial studies the following conditions: Relapsed/Refractory (R/R) Mature B Cell Non Hodgkin Lymphoma (NHL), Relapsed/Refractory (R/R) Angioimmunoblastic T-cell Lymphoma (AITL). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06393738?
The interventions under investigation include: Glofitamab (DRUG), ARV-393 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06393738?
This trial is sponsored by Arvinas, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06393738 being conducted?
This trial has 17 study locations across Connecticut, Michigan, New Jersey, New York, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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