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NCT06276400 · ClinicalTrials.gov registry record · NA
LPFC Organization in Emotion-Duration Difference Estimation
A NA study of Healthy, sponsored by University of California, Santa Barbara.
- Recruiting
- Registry status
- NA
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT06276400: Recruiting NA study of Healthy, sponsored by University of California, Santa Barbara.
NCT06276400 is a NA study of Healthy that is actively recruiting participants, run by University of California, Santa Barbara. The registered enrollment target is 50 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06276400, a NA study of Healthy, is actively recruiting participants, sponsored by University of California, Santa Barbara.
- RECRUITING
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
To support optimal behavior in daily life, goals and responses following emotional events should ideally incorporate not only the valence and intensity of prior emotional episodes but also their temporal features, such as the relative duration of positive vs. negative attributes. However, how specific brain regions contribute to the integration of temporal and emotional information and promote goal-directed response remains unknown. The goal of this study is to examine how specific brain regions track both emotional and temporal information of dynamic emotional events to inform other related brain regions to guide goal-oriented and context-appropriate actions. The investigators will scan healthy human participants using functional MRI (fMRI) while they view emotional image sequences and track the associated emotional and temporal (duration) information, and act accordingly. The investigators will employ multivariate patterns analysis and pattern similarity analysis to identify brain regions that represent (can decode) emotion, time, and their combined signals, as well as brain regions that represent the associated action goal. In addition, to infer the causal contributions of these brain regions in forming task-relevant representations (emotion, time, and action goal), the same participants will be recruited to receive transcranial magnetic stimulation (TMS) in these regions.
Primary Outcome
The investigators will use BOLD activation patterns measured from each ROI to fit quantitative models of emotional valence, time, and action goal encoding. These models will be used to classify stimulus representations on experimental trials to quantify how stimulus representations are encoded in each brain region studies, and how these representations change across experimental manipulations. These measurements will be used to test the impact of stimulus manipulations on stimulus representation
Conditions Studied
Interventions
- OTHER Emotion valence
- OTHER Time
- DEVICE TMS Stimulation
Study Locations (1)
California
- University of California, Santa Barbara - Santa Barbara
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2024-01-29 |
| Est. Completion | 2028-03-31 |
| Phase | NA |
What NCT06276400 shows while recruiting
NCT06276400 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 3 interventions - of which Emotion valence is the first listed.
NCT06276400 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06276400 about?
NCT06276400 is a clinical study titled "LPFC Organization in Emotion-Duration Difference Estimation". To support optimal behavior in daily life, goals and responses following emotional events should ideally incorporate not only the valence and intensity of prior emotional episodes but also their temporal features, such as the relative duration of positive vs. negative attributes. However, how specif...
What is the current status of trial NCT06276400?
This trial is currently recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2024-01-29. Estimated completion is 2028-03-31.
What conditions does trial NCT06276400 study?
This clinical trial studies the following conditions: Healthy.
What interventions are being tested in trial NCT06276400?
The interventions under investigation include: Emotion valence (OTHER), Time (OTHER), TMS Stimulation (DEVICE).
Who is sponsoring clinical trial NCT06276400?
This trial is sponsored by University of California, Santa Barbara, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06276400 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06276400's enrollment target sits among peer trials
50 448th of 1090 higher than 618 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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