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RECRUITING

Dentatorubral-pallidoluysian Atrophy Natural History and Biomarkers Study

NCT06273150 · View on ClinicalTrials.gov ↗

Study Summary

DRPLA Natural History and Biomarkers Study (DRPLA NHBS) is a prospective observational study that will lay the foundation for clinical trials in DRPLA. The aims of this project are: * To characterize the natural history of DRPLA in both juvenile- and adult-onset patients and study different modalities of biomarkers in this condition. * To identify genetic factors and biomarkers that could predict disease progression. * To provide a platform to support the design and conduct of clinical trials. This study has three arms: 1. Adult Participants: this arm of the study will require participants to be 16 years old or over to participate. 2. Pediatric Participants: this arm of the study will require participants to be under 16 years old to participate. 3. Remote Participants: patients that cannot or do not wish to travel to one of the study sites can participate in this arm of the study, irrespective of their age. Participants will have an annual visit for three years (baseline visit and two follow-up visits, three visits in total). Subjects who complete the whole protocol will be assessed on two consecutive days to reduce patient burden. This project will allow for a better understanding of DRPLA and its course, and therefore allow for future clinical trials on this condition to be more precisely and effectively conducted.

Interventions

  • OTHER Positive genetic test for pathological expansion in ATN1

Study Locations (3)

New York

  • NYU Grossman School of Medicine — New York

North Carolina

  • University of North Carolina at Chapel Hill — Chapel Hill

Other

  • University College London — London

Trial Details

FieldValue
Enrollment Target 225 participants
Start Date 2022-05-01
Est. Completion 2026-04

Sponsor

University College, London

6 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06273150

The ClinicalTrials.gov registry entry for NCT06273150 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 225 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University College, London, which has 6 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Dentatorubral-Pallidoluysian Atrophy appearing as the primary indexed condition, and to 1 intervention — of which Positive genetic test for pathological expansion in ATN1 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06273150 reports 3 study locations spanning 3 distinct geographic areas — top geographies include New York, North Carolina, Other. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06273150 about?

NCT06273150 is a clinical study titled "Dentatorubral-pallidoluysian Atrophy Natural History and Biomarkers Study". DRPLA Natural History and Biomarkers Study (DRPLA NHBS) is a prospective observational study that will lay the foundation for clinical trials in DRPLA. The aims of this project are: * To characterize the natural history of DRPLA in both juvenile- and adult-onset patients and study different modalit...

What is the current status of trial NCT06273150?

This trial is currently recruiting. The enrollment target is 225 participants. The study started on 2022-05-01. Estimated completion is 2026-04.

What conditions does trial NCT06273150 study?

This clinical trial studies the following conditions: Dentatorubral-Pallidoluysian Atrophy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06273150?

The interventions under investigation include: Positive genetic test for pathological expansion in ATN1 (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06273150?

This trial is sponsored by University College, London, which has 6 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06273150 being conducted?

This trial has 3 study locations across New York, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial