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NCT06273150 · ClinicalTrials.gov registry record
Dentatorubral-pallidoluysian Atrophy Natural History and Biomarkers Study
A clinical trial of Dentatorubral-Pallidoluysian Atrophy, sponsored by University College, London.
- Recruiting
- Registry status
- 225
- Enrollment target
- 3
- Study locations
NCT06273150 is a study of Dentatorubral-Pallidoluysian Atrophy that is actively recruiting participants, run by University College, London. The registered enrollment target is 225 participants. The trial reports 3 study locations across 3 states.
The verdict
NCT06273150, a study of Dentatorubral-Pallidoluysian Atrophy, is actively recruiting participants, sponsored by University College, London.
- RECRUITING
- Registry status
- 225 participants
- Enrollment target
- 3
- Study locations
Study Summary
DRPLA Natural History and Biomarkers Study (DRPLA NHBS) is a prospective observational study that will lay the foundation for clinical trials in DRPLA. The aims of this project are: * To characterize the natural history of DRPLA in both juvenile- and adult-onset patients and study different modalities of biomarkers in this condition. * To identify genetic factors and biomarkers that could predict disease progression. * To provide a platform to support the design and conduct of clinical trials. This study has three arms: 1. Adult Participants: this arm of the study will require participants to be 16 years old or over to participate. 2. Pediatric Participants: this arm of the study will require participants to be under 16 years old to participate. 3. Remote Participants: patients that cannot or do not wish to travel to one of the study sites can participate in this arm of the study, irrespective of their age. Participants will have an annual visit for three years (baseline visit and two follow-up visits, three visits in total). Subjects who complete the whole protocol will be assessed on two consecutive days to reduce patient burden. This project will allow for a better understanding of DRPLA and its course, and therefore allow for future clinical trials on this condition to be more precisely and effectively conducted.
Conditions Studied
Interventions
- OTHER Positive genetic test for pathological expansion in ATN1
Study Locations (3)
New York
- NYU Grossman School of Medicine - New York
North Carolina
- University of North Carolina at Chapel Hill - Chapel Hill
Other
- University College London - London
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 225 participants |
| Start Date | 2022-05-01 |
| Est. Completion | 2026-04 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06273150
The ClinicalTrials.gov registry entry for NCT06273150 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 225 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University College, London, which has 8 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Dentatorubral-Pallidoluysian Atrophy appearing as the primary indexed condition, and to 1 intervention - of which Positive genetic test for pathological expansion in ATN1 is the first listed.
NCT06273150 reports 3 study locations spanning 3 distinct geographic areas - top geographies include New York, North Carolina, Other.
Frequently Asked Questions
What is clinical trial NCT06273150 about?
NCT06273150 is a clinical study titled "Dentatorubral-pallidoluysian Atrophy Natural History and Biomarkers Study". DRPLA Natural History and Biomarkers Study (DRPLA NHBS) is a prospective observational study that will lay the foundation for clinical trials in DRPLA. The aims of this project are: * To characterize the natural history of DRPLA in both juvenile- and adult-onset patients and study different modalit...
What is the current status of trial NCT06273150?
This trial is currently recruiting. The enrollment target is 225 participants. The study started on 2022-05-01. Estimated completion is 2026-04.
What conditions does trial NCT06273150 study?
This clinical trial studies the following conditions: Dentatorubral-Pallidoluysian Atrophy.
What interventions are being tested in trial NCT06273150?
The interventions under investigation include: Positive genetic test for pathological expansion in ATN1 (OTHER).
Who is sponsoring clinical trial NCT06273150?
This trial is sponsored by University College, London, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06273150 being conducted?
This trial has 3 study locations across New York, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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