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RECRUITING Phase 2

A Phase II Trial of Sacituzumab Govitecan in Patients With Advanced Thymic Epithelial Tumors

NCT06248515 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this clinical trial is to study the effect of sacituzumab govitecan-hziy in adult patients with advanced thymoma and thymic carcinoma after progressing on at least one prior line of therapy. The main question it aims to answer is: • What is the overall response rate (ORR) in patients with advanced thymoma and thymic carcinoma? Participants will: * receive a fixed dose of 10 mg/kg given intravenously, once weekly on Days 1 and 8 of continuous 21-day treatment cycles until disease progression or unacceptable toxicity * have regular blood tests, scans, and examinations to monitor their health. * have blood and a biopsy of their tumor for research purposes.

Conditions Studied

Interventions

  • DRUG Sacituzumab govitecan-hziy

Study Locations (4)

California

  • Stanford Cancer Institute — Palo Alto

District of Columbia

  • Lombardi Comprehensive Cancer Center, Georgetown University — Washington D.C.

Illinois

  • University of Chicago Medical Center — Chicago

New Jersey

  • John Theurer Cancer Center at Hackensack University Medical Center — Hackensack

Trial Details

FieldValue
Enrollment Target 18 participants
Start Date 2024-04-25
Est. Completion 2026-12
Phase Phase 2

Sponsor

Georgetown University

109 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06248515

The ClinicalTrials.gov registry entry for NCT06248515 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 18 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Georgetown University, which has 109 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Thymoma appearing as the primary indexed condition, and to 1 intervention — of which Sacituzumab govitecan-hziy is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06248515 reports 4 study locations spanning 4 distinct geographic areas — top geographies include California, District of Columbia, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06248515 about?

NCT06248515 is a clinical study titled "A Phase II Trial of Sacituzumab Govitecan in Patients With Advanced Thymic Epithelial Tumors". The goal of this clinical trial is to study the effect of sacituzumab govitecan-hziy in adult patients with advanced thymoma and thymic carcinoma after progressing on at least one prior line of therapy. The main question it aims to answer is: • What is the overall response rate (ORR) in patients w...

What is the current status of trial NCT06248515?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 18 participants. The study started on 2024-04-25. Estimated completion is 2026-12.

What conditions does trial NCT06248515 study?

This clinical trial studies the following conditions: Thymoma, Thymic Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06248515?

The interventions under investigation include: Sacituzumab govitecan-hziy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06248515?

This trial is sponsored by Georgetown University, which has 109 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06248515 being conducted?

This trial has 4 study locations across California, District of Columbia, Illinois, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial