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S095035 as a Single Agent and in Combination in Adult Participants With Advanced or Metastatic Solid Tumors With Deletion of MTAP
NCT06188702 · View on ClinicalTrials.gov ↗
Study Summary
This is a first-in-human Phase 1/2, multicenter, open-label study of S095035 as single-agent, or in combination with TNG462 in adult participants with advanced or metastatic solid tumors with homozygous deletion of MTAP who have failed to respond to or have progressed after at least 1 prior treatment regimen, and for whom additional effective standard treatment is not available. S095035 is an oral methionine adenosyltransferase 2A \[MAT2A\] inhibitor. TNG462 is a protein arginine N-methyltransferase 5 \[PRMT5\] inhibitor.
Conditions Studied
Interventions
- DRUG S095035
- DRUG TNG462
Study Locations (20)
Other
- Townsville University Hospital — Douglas
- Royal Hobart Hospital — Hobart
- University Hospital Rigshospitalet — Copenhagen
- Odense Universitets Hospital — Odense
- Institut Bergonié — Bordeaux
- Centre Georges-François Leclerc — Dijon
- Hôpital de la Timone (Marseille) — Marseille
- Institut Gustave Roussy — Paris
- Charite Universitatsmedizin — Berlin
California
- University of California Los Angeles — Los Angeles
- University of California, San Francisco (Ucsf) School of Medicine — San Francisco
Florida
- Lake Mary Cancer Center - Florida Cancer Specialists & Research Institute — Lake Mary
Indiana
- Community Health Network — Indianapolis
Massachusetts
- Dana Farber Cancer Institue — Boston
North Carolina
- Duke University School of Medicine — Durham
Ohio
- Taylor Cancer Research Center — Maumee
Tennessee
- SCRI Oncology Partners — Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 342 participants |
| Start Date | 2024-04-29 |
| Est. Completion | 2031-10-31 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06188702
The ClinicalTrials.gov registry entry for NCT06188702 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 342 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Servier Bio-Innovation, which has 36 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with MTAP-deleted Solid Tumors appearing as the primary indexed condition, and to 2 interventions — of which S095035 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06188702 reports 20 study locations spanning 11 distinct geographic areas — top geographies include Other, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06188702 about?
NCT06188702 is a clinical study titled "S095035 as a Single Agent and in Combination in Adult Participants With Advanced or Metastatic Solid Tumors With Deletion of MTAP". This is a first-in-human Phase 1/2, multicenter, open-label study of S095035 as single-agent, or in combination with TNG462 in adult participants with advanced or metastatic solid tumors with homozygous deletion of MTAP who have failed to respond to or have progressed after at least 1 prior treatmen...
What is the current status of trial NCT06188702?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 342 participants. The study started on 2024-04-29. Estimated completion is 2031-10-31.
What conditions does trial NCT06188702 study?
This clinical trial studies the following conditions: MTAP-deleted Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06188702?
The interventions under investigation include: S095035 (DRUG), TNG462 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06188702?
This trial is sponsored by Servier Bio-Innovation, which has 36 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06188702 being conducted?
This trial has 20 study locations across California, Florida, Indiana, Massachusetts, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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