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NCT06112314 · ClinicalTrials.gov registry record · Phase 3
IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)
A Phase 3 study of Advanced Melanoma, sponsored by Immunocore.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 680
- Enrollment target
- 20
- Study locations
NCT06112314 is a Phase 3 study of Advanced Melanoma that is actively recruiting participants, run by Immunocore. The registered enrollment target is 680 participants, above the 139-participant average among 21 other Advanced Melanoma trials with a reported enrollment target (389% higher). The trial reports 20 study locations across 12 states.
The verdict
NCT06112314, a Phase 3 study of Advanced Melanoma, is actively recruiting participants, sponsored by Immunocore.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 680 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a phase 3, randomized, controlled study of brenetafusp (IMC-F106C) plus nivolumab compared to standard nivolumab regimens in HLA-A\*02:01-positive participants with previously untreated advanced melanoma.
Conditions Studied
Interventions
- DRUG Nivolumab
- DRUG Nivolumab + Relatlimab
- DRUG Brenetafusp
Study Locations (20)
California
- University of California - San Diego - La Jolla
- The Angeles Clinic and Research Institute- West Los Angeles - Los Angeles
- ESC Norris Comprehensive Cancer Center - Los Angeles
- UCLA Hematology/Oncology - Los Angeles
- Stanford Cancer Institute - Stanford Cancer Center Palo Alto - Palo Alto
- Saint John's Health Center - John Wayne Cancer Institute (JWCI) - Santa Monica
Colorado
- University of Colorado, Anschutz Medical Campus - Aurora
- The Melanoma & Skin Cancer Institute - Denver
Florida
- Mayo Clinic Florida - Jacksonville
- University of Miami Health System-Sylvester Comprehensive Cancer Center-Miami - Miami
Massachusetts
- Massachusetts General Hospital - Boston
- Dana Farber Cancer Institute - Boston
Arizona
- University of Arizona - Tucson
Connecticut
- UConn Health-Farmington (University of Connecticut Health Center (UCHC)) - Farmington
District of Columbia
- Georgetown University - Washington D.C.
Illinois
- Northwestern University - Robert H. Lurie Comprehensive Cancer Center - NMDTI - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 680 participants |
| Start Date | 2024-06-05 |
| Est. Completion | 2027-10-16 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06112314
The ClinicalTrials.gov registry entry for NCT06112314 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 680 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 139-participant average among 21 other Advanced Melanoma trials with a reported enrollment target (389% higher). The listed sponsor is Immunocore, which has 8 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Advanced Melanoma appearing as the primary indexed condition, and to 3 interventions - of which Nivolumab is the first listed.
NCT06112314 reports 20 study locations spanning 12 distinct geographic areas - top geographies include California, Colorado, Florida.
Frequently Asked Questions
What is clinical trial NCT06112314 about?
NCT06112314 is a clinical study titled "IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)". This is a phase 3, randomized, controlled study of brenetafusp (IMC-F106C) plus nivolumab compared to standard nivolumab regimens in HLA-A\*02:01-positive participants with previously untreated advanced melanoma.
What is the current status of trial NCT06112314?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 680 participants. The study started on 2024-06-05. Estimated completion is 2027-10-16.
What conditions does trial NCT06112314 study?
This clinical trial studies the following conditions: Advanced Melanoma.
What interventions are being tested in trial NCT06112314?
The interventions under investigation include: Nivolumab (DRUG), Nivolumab + Relatlimab (DRUG), Brenetafusp (DRUG).
Who is sponsoring clinical trial NCT06112314?
This trial is sponsored by Immunocore, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06112314 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Connecticut, District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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