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NCT06106646 · ClinicalTrials.gov registry record
Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) Longer Term Follow Up
A clinical trial of Asthma and Wheezing, sponsored by Oregon Health and Science University.
- Recruiting
- Registry status
- 225
- Enrollment target
- 2
- Study locations
NCT06106646: Recruiting study of Asthma and Wheezing, sponsored by Oregon Health and Science University.
NCT06106646 is a study of Asthma and Wheezing that is actively recruiting participants, run by Oregon Health and Science University. The registered enrollment target is 225 participants, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (86% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06106646, a study of Asthma and Wheezing, is actively recruiting participants, sponsored by Oregon Health and Science University.
- RECRUITING
- Registry status
- 225 participants
- Enrollment target
- 2
- Study locations
Study Summary
The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function at 10 years of age in their offspring. This is an additional continuation of the Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) trial, to follow the offspring through 10 years of age. The hypothesis for this protocol is an extension of the VCSIP trial that supplemental vitamin C in pregnant smokers can significantly improve their children's airway function tests. The investigators aim to demonstrate sustained improvement in airway/pulmonary function and trajectory through 10 years of age.
Primary Outcome
The primary outcome of this longitudinal follow-up study is the comparison of airway function tests (specifically FEF25-75 in liters/sec) measured yearly through 10 years of age by forced expiratory maneuvers with spirometry between the children of the pregnant smokers randomized to vitamin C (500 mg/day) versus placebo during pregnancy. This is a follow-up of the original "Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function" (VCSIP) trial.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT No active intervention in this protocol (previously randomized to Vitamin C)
- OTHER No active intervention in this protocol (previously randomized to Placebo)
Study Locations (2)
Indiana
- Indiana University - Indianapolis
Oregon
- Oregon Health and Science University (OHSU) - Portland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 225 participants |
| Start Date | 2023-10-11 |
| Est. Completion | 2028-08 |
What NCT06106646 shows while recruiting
NCT06106646 is an observational study that tracks outcomes without assigning an intervention. The registered 225 participants enrollment target is mid-sized for trials with a published cap, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (86% lower).
The record links to 4 conditions, with Asthma appearing as the primary indexed condition, and to 2 interventions - of which No active intervention in this protocol (previously randomized to Vitamin C) is the first listed.
NCT06106646 reports a single indexed study location in Indiana, Oregon.
Frequently Asked Questions
What is clinical trial NCT06106646 about?
NCT06106646 is a clinical study titled "Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) Longer Term Follow Up". The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function at 10 years of age in their offspring. This is an additional continuation of the Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung ...
What is the current status of trial NCT06106646?
This trial is currently recruiting. The enrollment target is 225 participants. The study started on 2023-10-11. Estimated completion is 2028-08.
What conditions does trial NCT06106646 study?
This clinical trial studies the following conditions: Asthma, Wheezing, Pulmonary Function, In Utero Nicotine.
What interventions are being tested in trial NCT06106646?
The interventions under investigation include: No active intervention in this protocol (previously randomized to Vitamin C) (DIETARY_SUPPLEMENT), No active intervention in this protocol (previously randomized to Placebo) (OTHER).
Who is sponsoring clinical trial NCT06106646?
This trial is sponsored by Oregon Health and Science University, which has 546 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06106646 being conducted?
This trial has 2 study locations across Indiana, Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06106646's enrollment target sits among peer trials
225 147th of 374 higher than 227 of 374 other Asthma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Asthma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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