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ACTIVE NOT RECRUITING

The CARDIO-TTRansform Scintigraphy Sub-study

NCT06073587 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to examine the changes in amyloid myocardial burden in a subset of the population participating in the ION682884-CS2 (NCT04136171) study, up to 150 participants, after treatment with eplontersen or placebo based on scintigraphy scans performed at Week 140 using the Perugini grade score method.

Interventions

  • DIAGNOSTIC_TEST Scintigraphy scan

Study Locations (5)

New York

  • Columbia University Irving Medical Center — New York

North Carolina

  • Duke University Medical Center — Durham

Ohio

  • Cleveland Clinic Main Campus — Cleveland

Oregon

  • Oregon Health and Science University — Portland

Other

  • Hospital Universitario Puerta de Hierro — Majadahonda

Trial Details

FieldValue
Enrollment Target 150 participants
Start Date 2023-04-04
Est. Completion 2026-03

Sponsor

Ionis Pharmaceuticals

55 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06073587

The ClinicalTrials.gov registry entry for NCT06073587 describes a study currently listed as active not recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 150 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Ionis Pharmaceuticals, which has 55 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM) appearing as the primary indexed condition, and to 1 intervention — of which Scintigraphy scan is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06073587 reports 5 study locations spanning 5 distinct geographic areas — top geographies include New York, North Carolina, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06073587 about?

NCT06073587 is a clinical study titled "The CARDIO-TTRansform Scintigraphy Sub-study". The purpose of this study is to examine the changes in amyloid myocardial burden in a subset of the population participating in the ION682884-CS2 (NCT04136171) study, up to 150 participants, after treatment with eplontersen or placebo based on scintigraphy scans performed at Week 140 using the Perug...

What is the current status of trial NCT06073587?

This trial is currently active not recruiting. The enrollment target is 150 participants. The study started on 2023-04-04. Estimated completion is 2026-03.

What conditions does trial NCT06073587 study?

This clinical trial studies the following conditions: Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06073587?

The interventions under investigation include: Scintigraphy scan (DIAGNOSTIC_TEST). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06073587?

This trial is sponsored by Ionis Pharmaceuticals, which has 55 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06073587 being conducted?

This trial has 5 study locations across New York, North Carolina, Ohio, Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial