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NCT06053294 · ClinicalTrials.gov registry record · NA
Neural and Metabolic Factors in Carbohydrate Reward
A NA study of Carbohydrate Metabolism, sponsored by Virginia Polytechnic Institute and State University.
- Recruiting
- Registry status
- NA
- Development phase
- 64
- Enrollment target
- 1
- Study location
NCT06053294 is a NA study of Carbohydrate Metabolism that is actively recruiting participants, run by Virginia Polytechnic Institute and State University. The registered enrollment target is 64 participants. The trial reports 1 study location across 1 state.
The verdict
NCT06053294, a NA study of Carbohydrate Metabolism, is actively recruiting participants, sponsored by Virginia Polytechnic Institute and State University.
- RECRUITING
- Registry status
- NA
- Development phase
- 64 participants
- Enrollment target
- 1
- Study location
Study Summary
Dietary factors contributed to nearly 50% of all cardiometabolic deaths in the US in 2012, making it one of the leading causes of preventable death in the US, second only to tobacco use. Human diets and food choices can't help but be influenced by the ubiquitous availability of processed foods of high-energy density and low nutrient content, consumption of which can lead to obesity, type II diabetes, heart disease, and other types of metabolic dysfunction. Surprisingly, food reinforcement does not rely on perceived energy density. Rather food reinforcement is associated with actual energy density and therefore, on an implicit knowledge of caloric content. That implicit knowledge must have a neural signature and a mechanism by which the gut communicates nutritive value to the brain. There is evidence, at least for fat and carbohydrates, that these pathways are separable, but terminate in a common neural structure, the dorsal striatum or caudate. This could be one mechanism by which modern processed foods high in both fat and carbohydrate are so sought after and readily consumed, In fact, when experimentally tested, fat and carbohydrate combinations were more reinforcing calorie for calorie than fat or carbohydrates alone and the level of reinforcement correlated with activity in reward- related brain areas. Beyond simple reinforcing value, it is known from the literature on drugs of abuse that the faster a drug is arrives at the brain, the higher it's abuse potential, however, little is known about how the kinetics of nutrient excursion influence food preference, choice, and brain activity. This project aims to test this specifically for carbohydrate reward.
Conditions Studied
Interventions
- OTHER CS- Beverage
- OTHER CS+Fast
- OTHER CS+Slow
Study Locations (1)
Virginia
- Fralin Biomedical Research Institute at VTC - Roanoke
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 64 participants |
| Start Date | 2023-05-01 |
| Est. Completion | 2029-05-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06053294
The ClinicalTrials.gov registry entry for NCT06053294 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 64 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Virginia Polytechnic Institute and State University, which has 104 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Carbohydrate Metabolism appearing as the primary indexed condition, and to 3 interventions - of which CS- Beverage is the first listed.
NCT06053294 reports 1 study location spanning 1 distinct geographic area - top geographies include Virginia.
Frequently Asked Questions
What is clinical trial NCT06053294 about?
NCT06053294 is a clinical study titled "Neural and Metabolic Factors in Carbohydrate Reward". Dietary factors contributed to nearly 50% of all cardiometabolic deaths in the US in 2012, making it one of the leading causes of preventable death in the US, second only to tobacco use. Human diets and food choices can't help but be influenced by the ubiquitous availability of processed foods of hi...
What is the current status of trial NCT06053294?
This trial is currently recruiting. It is a NA study. The enrollment target is 64 participants. The study started on 2023-05-01. Estimated completion is 2029-05-01.
What conditions does trial NCT06053294 study?
This clinical trial studies the following conditions: Carbohydrate Metabolism.
What interventions are being tested in trial NCT06053294?
The interventions under investigation include: CS- Beverage (OTHER), CS+Fast (OTHER), CS+Slow (OTHER).
Who is sponsoring clinical trial NCT06053294?
This trial is sponsored by Virginia Polytechnic Institute and State University, which has 104 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06053294 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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