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NCT05991700 · ClinicalTrials.gov registry record · Phase 1
Anthocyanin-Rich Table Grape Powder for Prophylaxis of Post-Operative Atrial Fibrillation
A Phase 1 study of Post-operative Atrial Fibrillation (POAF), sponsored by University of Michigan.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 70
- Enrollment target
- 1
- Study location
NCT05991700 is a Phase 1 study of Post-operative Atrial Fibrillation (POAF) that is actively recruiting participants, run by University of Michigan. The registered enrollment target is 70 participants. The trial reports 1 study location across 1 state.
The verdict
NCT05991700, a Phase 1 study of Post-operative Atrial Fibrillation (POAF), is actively recruiting participants, sponsored by University of Michigan.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery and leads to worse outcomes. POAF is thought to be caused by the inflammatory state following cardiac surgery. It may be that anti-inflammatory medications could lower the occurrence of POAF, however many typical anti-inflammatory medications, such as ibuprofen, are contraindicated in the post cardiac surgery patient due to increased risks of bleeding. If a drug was identified with anti-inflammatory properties with minimal deleterious side effects, this could be broadly applied to cardiac surgery patients for the prevention of POAF. Interestingly, several small trials have shown that medications that alter transcription of inflammatory markers lead to decreased POAF. Furthermore, we have shown that phytochemicals, such as those found in grapes, have excellent bioavailability and can affect cardiac gene transcription related to inflammation. In this study, we propose to evaluate the efficacy of preoperative administration of concentrated grape powder in the prevention of POAF.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Freeze-Dried California Table Grape
Study Locations (1)
Michigan
- University of Michigan - Michigan Medicine - Ann Arbor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2026-04 |
| Est. Completion | 2027-08 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05991700
The ClinicalTrials.gov registry entry for NCT05991700 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Michigan, which has 1,327 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Post-operative Atrial Fibrillation (POAF) appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05991700 reports 1 study location spanning 1 distinct geographic area - top geographies include Michigan.
Frequently Asked Questions
What is clinical trial NCT05991700 about?
NCT05991700 is a clinical study titled "Anthocyanin-Rich Table Grape Powder for Prophylaxis of Post-Operative Atrial Fibrillation". Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery and leads to worse outcomes. POAF is thought to be caused by the inflammatory state following cardiac surgery. It may be that anti-inflammatory medications could lower the occurrence of POAF, however many typ...
What is the current status of trial NCT05991700?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 70 participants. The study started on 2026-04. Estimated completion is 2027-08.
What conditions does trial NCT05991700 study?
This clinical trial studies the following conditions: Post-operative Atrial Fibrillation (POAF).
What interventions are being tested in trial NCT05991700?
The interventions under investigation include: Placebo (DRUG), Freeze-Dried California Table Grape (DRUG).
Who is sponsoring clinical trial NCT05991700?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05991700 being conducted?
This trial has 1 study location across Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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