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NCT05991700 · ClinicalTrials.gov registry record · Phase 1
Anthocyanin-Rich Table Grape Powder for Prophylaxis of Post-Operative Atrial Fibrillation
A Phase 1 study of Post-operative Atrial Fibrillation (POAF), sponsored by University of Michigan.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 70
- Enrollment target
- 1
- Study location
NCT05991700: Recruiting Phase 1 study of Post-operative Atrial Fibrillation (POAF), sponsored by University of Michigan.
NCT05991700 is a Phase 1 study of Post-operative Atrial Fibrillation (POAF) that is actively recruiting participants, run by University of Michigan. The registered enrollment target is 70 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (17% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05991700, a Phase 1 study of Post-operative Atrial Fibrillation (POAF), is actively recruiting participants, sponsored by University of Michigan.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery and leads to worse outcomes. POAF is thought to be caused by the inflammatory state following cardiac surgery. It may be that anti-inflammatory medications could lower the occurrence of POAF, however many typical anti-inflammatory medications, such as ibuprofen, are contraindicated in the post cardiac surgery patient due to increased risks of bleeding. If a drug was identified with anti-inflammatory properties with minimal deleterious side effects, this could be broadly applied to cardiac surgery patients for the prevention of POAF. Interestingly, several small trials have shown that medications that alter transcription of inflammatory markers lead to decreased POAF. Furthermore, we have shown that phytochemicals, such as those found in grapes, have excellent bioavailability and can affect cardiac gene transcription related to inflammation. In this study, we propose to evaluate the efficacy of preoperative administration of concentrated grape powder in the prevention of POAF.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Freeze-Dried California Table Grape
Study Locations (1)
Michigan
- University of Michigan - Michigan Medicine - Ann Arbor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2026-04 |
| Est. Completion | 2027-08 |
| Phase | Phase 1 |
What NCT05991700 shows while recruiting
NCT05991700 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (17% higher).
The record links to 1 condition, with Post-operative Atrial Fibrillation (POAF) appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05991700 reports a single indexed study location in Michigan.
Frequently Asked Questions
What is clinical trial NCT05991700 about?
NCT05991700 is a clinical study titled "Anthocyanin-Rich Table Grape Powder for Prophylaxis of Post-Operative Atrial Fibrillation". Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery and leads to worse outcomes. POAF is thought to be caused by the inflammatory state following cardiac surgery. It may be that anti-inflammatory medications could lower the occurrence of POAF, however many typ...
What is the current status of trial NCT05991700?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 70 participants. The study started on 2026-04. Estimated completion is 2027-08.
What conditions does trial NCT05991700 study?
This clinical trial studies the following conditions: Post-operative Atrial Fibrillation (POAF).
What interventions are being tested in trial NCT05991700?
The interventions under investigation include: Placebo (DRUG), Freeze-Dried California Table Grape (DRUG).
Who is sponsoring clinical trial NCT05991700?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05991700 being conducted?
This trial has 1 study location across Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05991700's enrollment target sits among peer trials
70 749th of 2000 higher than 1,227 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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