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ACTIVE NOT RECRUITING Phase 3

REZILIENT3 (REsearching ZIpaLertinib In Egfr Non-small Cell Lung Cancer Tumors)

NCT05973773 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the safety and efficacy of zipalertinib in combination with standard first-line platinum-based chemotherapy compared to chemotherapy alone, in patients with locally advanced or metastatic NSCLC with EGFR ex20ins mutations.

Interventions

  • DRUG TAS6417

Study Locations (20)

Nevada

  • Comprehensive Cancer Centers of Nevada - Henderson — Henderson
  • Comprehensive Cancer Centers of Nevada - Horizon Ridge Henderson — Henderson
  • Comprehensive Cancer Centers of Nevada - Southeast Henderson - Stephanie — Henderson
  • Comprehensive Cancer Centers of Nevada - Summerlin Medical Center II — Las Vegas
  • Comprehensive Cancer Centers of Nevada - Southwest — Las Vegas
  • Comprehensive Cancer Centers of Nevada - Central Valley - Twain — Las Vegas
  • Comprehensive Cancer Centers of Nevada - Northwest — Las Vegas

Rio Grande do Sul

  • Hospital Mãe de Deus - Centro Integrado de Oncologia — Porto Alegre
  • Hospital São Lucas da PUCRS — Porto Alegre

Ohio

  • Gabrail Cancer and Research Center — Canton

Texas

  • University of Texas MD Anderson Cancer Center — Houston

Flemish Brabant

  • Universitair Ziekenhuis Leuven - Campus Gasthuisberg — Leuven

Oost-Vlaaderen

  • Algemeen Ziekenhuis Maria Middelares — Ghent

West Flanders

  • Algemeen Ziekenhuis Delta - Campus Menen — Menen

West-Vlaanderen

  • Algemeen Ziekenhuis Delta - Campus Rumbeke — Rosières

Trial Details

FieldValue
Enrollment Target 285 participants
Start Date 2023-12-18
Est. Completion 2027-05-27
Phase Phase 3

Sponsor

Taiho Oncology

46 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05973773

The ClinicalTrials.gov registry entry for NCT05973773 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 285 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Taiho Oncology, which has 46 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation appearing as the primary indexed condition, and to 1 intervention — of which TAS6417 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05973773 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Nevada, Rio Grande do Sul, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05973773 about?

NCT05973773 is a clinical study titled "REZILIENT3 (REsearching ZIpaLertinib In Egfr Non-small Cell Lung Cancer Tumors)". The purpose of this study is to evaluate the safety and efficacy of zipalertinib in combination with standard first-line platinum-based chemotherapy compared to chemotherapy alone, in patients with locally advanced or metastatic NSCLC with EGFR ex20ins mutations.

What is the current status of trial NCT05973773?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 285 participants. The study started on 2023-12-18. Estimated completion is 2027-05-27.

What conditions does trial NCT05973773 study?

This clinical trial studies the following conditions: Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05973773?

The interventions under investigation include: TAS6417 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05973773?

This trial is sponsored by Taiho Oncology, which has 46 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05973773 being conducted?

This trial has 20 study locations across Nevada, Ohio, Texas, Flemish Brabant, Oost-Vlaaderen. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial