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A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies
NCT05957367 · View on ClinicalTrials.gov ↗
Study Summary
This is a Phase 1/2, multicenter, open-label (unless otherwise specified in a combination-specific module) study of inlexisertib in combination with anticancer therapies. Modules within the master protocol are defined according to different combinations of inlexisertib with other anticancer agents.
Conditions Studied
Interventions
- DRUG Inlexisertib
- DRUG Ripretinib
Study Locations (14)
Other
- Antonie Van Leeuwenhoek Hospital — Amsterdam
- Radboudumc — Nijmegen
- Inselspital Universitätsklinikum Bern — Bern
California
- University of Southern California - Norris Comprehensive Cancer Center — Los Angeles
- UCLA Department of Medicine-Hematology/Oncology — Los Angeles
Florida
- Sylvester Comprehensive Cancer Center — Miami
Massachusetts
- University of Massachusetts Worcester — Worcester
Michigan
- START Midwest — Grand Rapids
Missouri
- Washington University School of Medicine - Siteman Cancer Center — St Louis
New York
- Memorial Sloan Kettering Cancer Center - Main Campus — New York
Ohio
- Cleveland Clinic Taussig Cancer Center — Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 94 participants |
| Start Date | 2023-09-28 |
| Est. Completion | 2029-03 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05957367
The ClinicalTrials.gov registry entry for NCT05957367 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 94 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Deciphera Pharmaceuticals, which has 42 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with GIST appearing as the primary indexed condition, and to 2 interventions — of which Inlexisertib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05957367 reports 14 study locations spanning 11 distinct geographic areas — top geographies include Other, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05957367 about?
NCT05957367 is a clinical study titled "A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies". This is a Phase 1/2, multicenter, open-label (unless otherwise specified in a combination-specific module) study of inlexisertib in combination with anticancer therapies. Modules within the master protocol are defined according to different combinations of inlexisertib with other anticancer agents.
What is the current status of trial NCT05957367?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 94 participants. The study started on 2023-09-28. Estimated completion is 2029-03.
What conditions does trial NCT05957367 study?
This clinical trial studies the following conditions: GIST. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05957367?
The interventions under investigation include: Inlexisertib (DRUG), Ripretinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05957367?
This trial is sponsored by Deciphera Pharmaceuticals, which has 42 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05957367 being conducted?
This trial has 14 study locations across California, Florida, Massachusetts, Michigan, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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