Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05933577 · ClinicalTrials.gov registry record · Phase 3
A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)
A Phase 3 study of Melanoma, sponsored by Merck Sharp & Dohme.
- Active
- Registry status
- Phase 3
- Development phase
- 1,089
- Enrollment target
- 20
- Study locations
NCT05933577 is a Phase 3 study of Melanoma that is active but no longer recruiting, run by Merck Sharp & Dohme. The registered enrollment target is 1,089 participants, above the 702-participant average among 266 other Melanoma trials with a reported enrollment target (55% higher). The trial reports 20 study locations across 11 states.
The verdict
NCT05933577, a Phase 3 study of Melanoma, is active but no longer recruiting, sponsored by Merck Sharp & Dohme.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 1,089 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this study is to learn if intismeran autogene which is an individualized neoantigen therapy (INT; formerly, called messenger ribonucleic acid \[mRNA\]-4157) with pembrolizumab (MK-3475) is safe and prevents cancer from returning in people with high-risk melanoma. Researchers want to know if intismeran autogene with pembrolizumab is better than receiving pembrolizumab alone at preventing the cancer from returning.
Conditions Studied
Interventions
- BIOLOGICAL Pembrolizumab
- OTHER Placebo
- BIOLOGICAL Intismeran autogene
Study Locations (20)
Massachusetts
- Massachusetts General Hospital ( Site 1927) - Boston
- Beth Israel Deaconess Medical Center ( Site 1957) - Boston
- Dana-Farber Cancer Institute ( Site 1956) - Boston
New Jersey
- John Theurer Cancer Center at Hackensack University Medical Center ( Site 1944) - Hackensack
- Atlantic Health System ( Site 1925) - Morristown
- Valley Health Systems - Ridgewood Campus ( Site 1947) - Ridgewood
California
- UCLA Hematology/Oncology - Westwood (Building 100) ( Site 1918) - Los Angeles
- UCSF Medical Center at Mission Bay ( Site 1929) - San Francisco
Florida
- Orlando Health Cancer Institute ( Site 1937) - Orlando
- Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center ( Site 1945) - Tampa
Georgia
- Winship Cancer Institute of Emory University ( Site 1940) - Atlanta
- Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 1950) - Marietta
Michigan
- University of Michigan ( Site 1915) - Ann Arbor
- Cancer and Hematology Centers of Western Michigan ( Site 1932) - Grand Rapids
New York
- Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 1958) - Mineola
- NYU Langone Health-Perlmutter Cancer Center ( Site 1917) - New York
Arkansas
- Highlands Oncology Group ( Site 1943) - Springdale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,089 participants |
| Start Date | 2023-07-19 |
| Est. Completion | 2030-09-26 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05933577
The ClinicalTrials.gov registry entry for NCT05933577 describes a study currently listed as active not recruiting, categorized as Phase 3. The registered enrollment target is 1,089 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 702-participant average among 266 other Melanoma trials with a reported enrollment target (55% higher). The listed sponsor is Merck Sharp & Dohme, which has 558 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Melanoma appearing as the primary indexed condition, and to 3 interventions - of which Pembrolizumab is the first listed.
NCT05933577 reports 20 study locations spanning 11 distinct geographic areas - top geographies include Massachusetts, New Jersey, California.
Frequently Asked Questions
What is clinical trial NCT05933577 about?
NCT05933577 is a clinical study titled "A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)". The purpose of this study is to learn if intismeran autogene which is an individualized neoantigen therapy (INT; formerly, called messenger ribonucleic acid \[mRNA\]-4157) with pembrolizumab (MK-3475) is safe and prevents cancer from returning in people with high-risk melanoma. Researchers want to k...
What is the current status of trial NCT05933577?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 1,089 participants. The study started on 2023-07-19. Estimated completion is 2030-09-26.
What conditions does trial NCT05933577 study?
This clinical trial studies the following conditions: Melanoma.
What interventions are being tested in trial NCT05933577?
The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Placebo (OTHER), Intismeran autogene (BIOLOGICAL).
Who is sponsoring clinical trial NCT05933577?
This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05933577 being conducted?
This trial has 20 study locations across Arkansas, California, Connecticut, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Melanoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
RECRUITING · Phase 3
-
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
RECRUITING · Phase 3
-
Randomized Study Comparing Two Dosing Schedules for Hypofractionated Image-Guided Radiation Therapy
ACTIVE NOT RECRUITING · Phase 3
-
A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma
ACTIVE NOT RECRUITING · Phase 3
-
Effectiveness Study of Nivolumab Compared to Placebo in Prevention of Recurrent Melanoma After Complete Resection of Stage IIB/C Melanoma
ACTIVE NOT RECRUITING · Phase 3
-
A Study to Evaluate ABP 206 Compared With OPDIVO® (Nivolumab) in Subjects With Unresectable or Metastatic Melanoma
ACTIVE NOT RECRUITING · Phase 3
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.