Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT05859269 · ClinicalTrials.gov registry record · Phase 4

Methylprednisolone Taper After Total Knee Replacement

A Phase 4 study of Knee Arthritis, sponsored by Emory University.

Completed
Registry status
Phase 4
Development phase
101
Enrollment target
2
Study locations

NCT05859269 is a Phase 4 study of Knee Arthritis that has completed, run by Emory University. The registered enrollment target is 101 participants, below the 126-participant average among 7 other Knee Arthritis trials with a reported enrollment target (20% lower). The trial reports 2 study locations across 1 state.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT05859269, a Phase 4 study of Knee Arthritis, has completed, sponsored by Emory University.

COMPLETED
Registry status
Phase 4
Development phase
101 participants
Enrollment target
2
Study locations

Study Summary

Total knee replacement surgery is a commonly performed and widely successful surgery to improve mobility and decrease pain in patients suffering from severe knee arthritis. However, in the immediate period after knee replacement, patients often experience significant pain and nausea, which can limit early recovery after surgery. Glucocorticoids are anti-inflammatory drugs that can reduce pain and swelling by blocking the inflammatory process, and have already shown promise in various surgical settings, including after knee replacement. There are different glucocorticoid formulations available, and in this particular study, we are evaluating the effects of administering a Medrol Dose Pak, which is a commonly available glucocorticoid taper that is administered over a short period of time after surgery. Our hypothesis is that the administration of the Medrol Dose Pak will lead to decreased pain, nausea, and opioid consumption in the weeks following total knee replacement.

Conditions Studied

Knee Arthritis

Interventions

  • OTHER Standard of Care
  • DRUG Methylprednisolone

Study Locations (2)

Georgia

  • Emory Musculoskeletal Institute - Atlanta
  • Emory University Orthopaedics & Spine Hospital - Tucker

Trial Details

FieldValue
Enrollment Target 101 participants
Start Date 2023-10-16
Est. Completion 2025-07-23
Phase Phase 4

Sponsor

Emory University

1,208 total trials

Interested in This Trial?

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05859269

The ClinicalTrials.gov registry entry for NCT05859269 describes a study currently listed as completed, categorized as Phase 4. The registered enrollment target is 101 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 126-participant average among 7 other Knee Arthritis trials with a reported enrollment target (20% lower). The listed sponsor is Emory University, which has 1,208 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Knee Arthritis appearing as the primary indexed condition, and to 2 interventions - of which Standard of Care is the first listed.

NCT05859269 reports 2 study locations spanning 1 distinct geographic area - top geographies include Georgia.

Frequently Asked Questions

What is clinical trial NCT05859269 about?

NCT05859269 is a clinical study titled "Methylprednisolone Taper After Total Knee Replacement". Total knee replacement surgery is a commonly performed and widely successful surgery to improve mobility and decrease pain in patients suffering from severe knee arthritis. However, in the immediate period after knee replacement, patients often experience significant pain and nausea, which can limit...

What is the current status of trial NCT05859269?

This trial is currently completed. It is a Phase 4 study. The enrollment target is 101 participants. The study started on 2023-10-16. Estimated completion is 2025-07-23.

What conditions does trial NCT05859269 study?

This clinical trial studies the following conditions: Knee Arthritis.

What interventions are being tested in trial NCT05859269?

The interventions under investigation include: Standard of Care (OTHER), Methylprednisolone (DRUG).

Who is sponsoring clinical trial NCT05859269?

This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05859269 being conducted?

This trial has 2 study locations across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Knee Arthritis

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Explore more on PlainTrial

Knee Arthritis

All registered trials for this condition

Georgia

All trials with a study site in Georgia

Recruiting now

Find trials open to new participants near you

Rankings

Top sponsors, conditions, and phases

Read our methodology - how this data is sourced, computed, and verified.

Related

Browse all → | Rankings →
Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.