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Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy
NCT05844982 · View on ClinicalTrials.gov ↗
Study Summary
This randomized controlled trial will evaluate the effect of intravitreal faricimab or fluocinolone acetonide (FAc) intravitreal implant compared with observation on long-term visual acuity following treatment of choroidal melanoma with iodine-125 plaque brachytherapy.
Conditions Studied
Interventions
- DRUG Faricimab
- DRUG fluocinolone acetonide
Study Locations (20)
Pennsylvania
- Retina-Vitreous Consultants, Inc. — Monroeville
- Wills Eye Hospital — Philadelphia
- Pittsburgh Clinical Trial Consortium — Sewickley
Illinois
- Northwestern Memorial Group — Chicago
- IL Eye and Ear Infirmary-University of Illinois at Chicago — Chicago
Michigan
- Foundation for Vision Research and Retina Specialists of Michigan, P.C. — Grand Rapids
- Associated Retinal Consultants, P.C. — Royal Oak
Texas
- Retina Consultants of Texas, PA — Bellaire
- UT Southwestern Medical Center — Dallas
California
- Byers Eye Institute at Stanford University — Palo Alto
Connecticut
- Retina Consultants — Manchester
Florida
- Retina Associates of Florida, LLC — Tampa
Indiana
- Midwest Eye Institute — Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 600 participants |
| Start Date | 2023-11-21 |
| Est. Completion | 2029-12-26 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05844982
The ClinicalTrials.gov registry entry for NCT05844982 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 600 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Jaeb Center for Health Research, which has 134 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Visual Impairment appearing as the primary indexed condition, and to 2 interventions — of which Faricimab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05844982 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Pennsylvania, Illinois, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05844982 about?
NCT05844982 is a clinical study titled "Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy". This randomized controlled trial will evaluate the effect of intravitreal faricimab or fluocinolone acetonide (FAc) intravitreal implant compared with observation on long-term visual acuity following treatment of choroidal melanoma with iodine-125 plaque brachytherapy.
What is the current status of trial NCT05844982?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 600 participants. The study started on 2023-11-21. Estimated completion is 2029-12-26.
What conditions does trial NCT05844982 study?
This clinical trial studies the following conditions: Visual Impairment, Radiation Retinopathy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05844982?
The interventions under investigation include: Faricimab (DRUG), fluocinolone acetonide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05844982?
This trial is sponsored by Jaeb Center for Health Research, which has 134 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05844982 being conducted?
This trial has 20 study locations across California, Connecticut, Florida, Illinois, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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