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NCT05649384 · ClinicalTrials.gov registry record · NA
Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm (PRESC1SE-MI)
A NA study of NSTEMI - Non-ST Segment Elevation MI and Acute Chest Pain, sponsored by University Hospital, Basel, Switzerland.
- Active
- Registry status
- NA
- Development phase
- 64,374
- Enrollment target
- 20
- Study locations
NCT05649384: Active NA study of NSTEMI - Non-ST Segment Elevation MI and Acute Chest Pain, sponsored by University Hospital, Basel, Switzerland.
NCT05649384 is a NA study of NSTEMI - Non-ST Segment Elevation MI and Acute Chest Pain that is active but no longer recruiting, run by University Hospital, Basel, Switzerland. The registered enrollment target is 64,374 participants, above the 334-participant average among 4 other NSTEMI - Non-ST Segment Elevation MI trials with a reported enrollment target (19174% higher). The trial reports 20 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05649384, a NA study of NSTEMI - Non-ST Segment Elevation MI and Acute Chest Pain, is active but no longer recruiting, sponsored by University Hospital, Basel, Switzerland.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 64,374 participants
- Enrollment target
- 20
- Study locations
Study Summary
The PRESC1SE-MI study compares two algorithms for triage of patients presenting with chest pain and symptoms of heart attack (myocardial infarction) to the emergency department. Both algorithms are recommended by the European Society of Cardiology: the 0/3-hour algorithm and the 0/1-hour algorithm. Currently, most emergency departments worldwide use the 0/3-hour troponin algorithm. Cardiac troponin (cTn) is a heart-specific biomarker which indicates damage of the heart muscle and which increases after a heart attack. In the 0/3-hour algorithm, the amount of troponin in the bloodstream is measured with a high-sensitivity assay at admission and 3 hours thereafter. Likewise, the 0/1-hour algorithm means that the blood sample in which the troponin is measured is collected at admission and 1 hour later. Since recent clinical studies suggest that the 0/1-hour algorithm is superior to the 0/3-hour algorithm, many hospitals consider switching to the 0/1-hour algorithm. The aim of this study is to assess how feasible the time-saving 0/1-hour algorithm would be in reality and whether it provides the same accuracy and safety in the diagnosis of myocardial infarction as the current practice the 0/3-hour algorithm.
Primary Outcome
Mortality rate and number of newly diagnosed AMI (type 1) in all enrolled patients
Conditions Studied
Interventions
- DIAGNOSTIC_TEST European Society of Cardiology hs-cTnT/I 0 h/1 h algorithm
- DIAGNOSTIC_TEST European Society of Cardiology hs-cTnT/I 0 h/3 h algorithm
Study Locations (20)
Other
- St Andrew's War Memorial Hospital Brisbane - Brisbane
- Vienna General Hospital (AKH Wien) - Vienna
- University Central Hospital Helsinki - Helsinki
- Attikon General Hospital Athens - Athens
- Careggi University Hospital Florence - Florence
- Azienda Ospedaliera San Giovanni Addolorata - Roma
- Hospital Città della Salute e della Scienza di Torino - Torino
- Emergency Institute for Cardiovascular Diseases C.C. Iliescu - Bucharest
- Konkuk University Medical Center - Seoul
- Hospital Clinic Barcelona - Barcelona
- University Hospital October 12 Madrid - Madrid
- University Hospital Ramon y Cajal - Madrid
- Hospital Clínico Universitario Valencia - Valencia
- Kantonsspital Aarau - Aarau
- St. Claraspital - Basel
- Kantonsspital Luzern - Lucerne
- University Hospital Zurich - Zurich
- Royal London Hospital - London
- Royal Cornwall Hospitals Treliske - Truro
Texas
- Baylor St. Luke's Medical Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 64,374 participants |
| Start Date | 2020-12-01 |
| Est. Completion | 2028-05-31 |
| Phase | NA |
What the registry record for NCT05649384 still lists
NCT05649384 is an interventional study that assigns participants to a tested intervention. Its 64,374 participants enrollment target places it among the larger protocols in the corpus, above the 334-participant average among 4 other NSTEMI - Non-ST Segment Elevation MI trials with a reported enrollment target (19174% higher).
The record links to 2 conditions, with NSTEMI - Non-ST Segment Elevation MI appearing as the primary indexed condition, and to 2 interventions - of which European Society of Cardiology hs-cTnT/I 0 h/1 h algorithm is the first listed.
NCT05649384 names 20 study sites across 2 states, led by Other, Texas.
Frequently Asked Questions
What is clinical trial NCT05649384 about?
NCT05649384 is a clinical study titled "Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm (PRESC1SE-MI)". The PRESC1SE-MI study compares two algorithms for triage of patients presenting with chest pain and symptoms of heart attack (myocardial infarction) to the emergency department. Both algorithms are recommended by the European Society of Cardiology: the 0/3-hour algorithm and the 0/1-hour algorithm. ...
What is the current status of trial NCT05649384?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 64,374 participants. The study started on 2020-12-01. Estimated completion is 2028-05-31.
What conditions does trial NCT05649384 study?
This clinical trial studies the following conditions: NSTEMI - Non-ST Segment Elevation MI, Acute Chest Pain.
What interventions are being tested in trial NCT05649384?
The interventions under investigation include: European Society of Cardiology hs-cTnT/I 0 h/1 h algorithm (DIAGNOSTIC_TEST), European Society of Cardiology hs-cTnT/I 0 h/3 h algorithm (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05649384?
This trial is sponsored by University Hospital, Basel, Switzerland, which has 12 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05649384 being conducted?
This trial has 20 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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