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NCT05609253 · ClinicalTrials.gov registry record · Phase 1
Itraconazole to Prevent Recurrent Barrett's Esophagus
A Phase 1 study of Barrett Oesophagitis With Dysplasia, sponsored by University of Kansas Medical Center.
- Active
- Registry status
- Phase 1
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT05609253 is a Phase 1 study of Barrett Oesophagitis With Dysplasia that is active but no longer recruiting, run by University of Kansas Medical Center. The registered enrollment target is 10 participants. The trial reports 1 study location across 1 state.
The verdict
NCT05609253, a Phase 1 study of Barrett Oesophagitis With Dysplasia, is active but no longer recruiting, sponsored by University of Kansas Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
Recurrent Barrett's esophagus (BE) that occurs at the rate of 12.4%/year is the Achilles heel of the endoscopic treatment of high-risk BE. Over time, after eradication, BE ultimately recurs in as many as 30-50% of the patients putting them at risk for esophageal adenocarcinoma (EAC), thereby undoing the benefits of an effective initial therapy. Also, recurrences need retreatments that increase costs and complications including strictures and refractory ulcerations. A therapy to prevent recurrent BE does not currently exist. Itraconazole with its ability to inhibit important molecular pathways related to BE development could enhance the long-term effectiveness of endoscopic eradication of high-risk BE, thereby promoting a long-term cure
Conditions Studied
Interventions
- DRUG Itraconazole in capsule form
- DRUG Itraconazole in solution form
Study Locations (1)
Kansas
- University of Kansas Medical Center - Kansas City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2022-09-14 |
| Est. Completion | 2026-06-30 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05609253
The ClinicalTrials.gov registry entry for NCT05609253 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 10 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Kansas Medical Center, which has 408 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Barrett Oesophagitis With Dysplasia appearing as the primary indexed condition, and to 2 interventions - of which Itraconazole in capsule form is the first listed.
NCT05609253 reports 1 study location spanning 1 distinct geographic area - top geographies include Kansas.
Frequently Asked Questions
What is clinical trial NCT05609253 about?
NCT05609253 is a clinical study titled "Itraconazole to Prevent Recurrent Barrett's Esophagus". Recurrent Barrett's esophagus (BE) that occurs at the rate of 12.4%/year is the Achilles heel of the endoscopic treatment of high-risk BE. Over time, after eradication, BE ultimately recurs in as many as 30-50% of the patients putting them at risk for esophageal adenocarcinoma (EAC), thereby undoing...
What is the current status of trial NCT05609253?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 10 participants. The study started on 2022-09-14. Estimated completion is 2026-06-30.
What conditions does trial NCT05609253 study?
This clinical trial studies the following conditions: Barrett Oesophagitis With Dysplasia.
What interventions are being tested in trial NCT05609253?
The interventions under investigation include: Itraconazole in capsule form (DRUG), Itraconazole in solution form (DRUG).
Who is sponsoring clinical trial NCT05609253?
This trial is sponsored by University of Kansas Medical Center, which has 408 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05609253 being conducted?
This trial has 1 study location across Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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