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NCT05593523 · ClinicalTrials.gov registry record
Fluorescence-based Detection of Inflammation and Necrosis to Inform Surgical Decision-making and Enhance Outcomes
A clinical trial of Burn Wound, sponsored by University of Wisconsin, Madison.
- Active
- Registry status
- 100
- Enrollment target
- 1
- Study location
NCT05593523: Active study of Burn Wound, sponsored by University of Wisconsin, Madison.
NCT05593523 is a study of Burn Wound that is active but no longer recruiting, run by University of Wisconsin, Madison. The registered enrollment target is 100 participants, above the 52-participant average among 3 other Burn Wound trials with a reported enrollment target (92% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05593523, a study of Burn Wound, is active but no longer recruiting, sponsored by University of Wisconsin, Madison.
- ACTIVE NOT RECRUITING
- Registry status
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
This study investigates fluorescence image-guided surgery to allow precise identification of necrotic tissue both preoperatively and intraoperatively in burn patients. Furthermore, it uses a multi-model approach to elucidate the localization of ICG in inflammation and necrosis to determine how this novel use of a well-known fluorescence marker can be optimized to aid in surgical decision making. This proposal will provide the necessary data to support the design of a larger clinical trial to study the feasibility and efficacy of this technology to improve the precision of necrosis detection and removal and improve wound healing outcomes. Up to 100 participants will be on study for up to approximately 24 days.
Primary Outcome
Quantitative assessment of all ICGA and SWIG fluorescence images will be achieved in part by measuring the fluorescence signal-to-background ratio (SBR).
Conditions Studied
Interventions
- DRUG Indocyanine green (ICG)
- DEVICE Clinical Fluorescence Imaging Device
Study Locations (1)
Wisconsin
- University of Wisconsin - Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2023-03-09 |
| Est. Completion | 2028-03 |
What the registry record for NCT05593523 still lists
NCT05593523 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, above the 52-participant average among 3 other Burn Wound trials with a reported enrollment target (92% higher).
The record links to 1 condition, with Burn Wound appearing as the primary indexed condition, and to 2 interventions - of which Indocyanine green (ICG) is the first listed.
NCT05593523 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT05593523 about?
NCT05593523 is a clinical study titled "Fluorescence-based Detection of Inflammation and Necrosis to Inform Surgical Decision-making and Enhance Outcomes". This study investigates fluorescence image-guided surgery to allow precise identification of necrotic tissue both preoperatively and intraoperatively in burn patients. Furthermore, it uses a multi-model approach to elucidate the localization of ICG in inflammation and necrosis to determine how this ...
What is the current status of trial NCT05593523?
This trial is currently active not recruiting. The enrollment target is 100 participants. The study started on 2023-03-09. Estimated completion is 2028-03.
What conditions does trial NCT05593523 study?
This clinical trial studies the following conditions: Burn Wound.
What interventions are being tested in trial NCT05593523?
The interventions under investigation include: Indocyanine green (ICG) (DRUG), Clinical Fluorescence Imaging Device (DEVICE).
Who is sponsoring clinical trial NCT05593523?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05593523 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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