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A Study of mRNA-1647 Cytomegalovirus Vaccine in Healthy Participants 9 to 15 Years of Age and Participants 16 to 25 Years of Age
NCT05575492 · View on ClinicalTrials.gov ↗
Study Summary
The main purpose of study is to evaluate the safety and immunogenicity of different dose levels of mRNA-1647 versus control in healthy cytomegalovirus (CMV)-seronegative and CMV-seropositive female and male participants 9 to 15 years of age. In addition, mRNA-1647 will be evaluated in female participants 16 to 25 years as a comparator cohort.
Conditions Studied
Interventions
- OTHER Placebo
- BIOLOGICAL mRNA-1647
Study Locations (20)
Florida
- Prohealth Research Center — Doral
- University of Florida Jacksonville — Jacksonville
- Clinical Neurosciences Solutions Inc. (Orlando-East South St) — Orlando
- Palm Harbor Dermatology — Tampa
- Santos Research Center — Tampa
California
- Paradigm Clinical Research Institute Inc - ClinEdge - PPDS — La Mesa
- Velocity Clinical Research - San Diego - PPDS — La Mesa
- Benchmark Research - Sacramento -Hypercore- PPDS — Sacramento
Maryland
- University of Maryland School of Medicine — Baltimore
- The Pediatric Centre — Columbia
- The Pediatric Centre of Frederick — Frederick
Georgia
- Children's Healthcare of Atlanta — Atlanta
- iResearch Atlanta - CenExel - PPDS — Decatur
Louisiana
- Benchmark Research - Covington - HyperCore- PPDS — Covington
- Tulane Medical Center — New Orleans
Colorado
- Tekton Research - Fort Collins - Platinum - PPDS — Fort Collins
District of Columbia
- Velocity Clinical Research (Washington)- PPDS — Washington D.C.
Idaho
- Clinical Research Prime - ClinEdge - PPDS — Idaho Falls
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 873 participants |
| Start Date | 2022-11-07 |
| Est. Completion | 2027-01-15 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05575492
The ClinicalTrials.gov registry entry for NCT05575492 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 873 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ModernaTX, which has 67 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Cytomegalovirus appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05575492 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Florida, California, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05575492 about?
NCT05575492 is a clinical study titled "A Study of mRNA-1647 Cytomegalovirus Vaccine in Healthy Participants 9 to 15 Years of Age and Participants 16 to 25 Years of Age". The main purpose of study is to evaluate the safety and immunogenicity of different dose levels of mRNA-1647 versus control in healthy cytomegalovirus (CMV)-seronegative and CMV-seropositive female and male participants 9 to 15 years of age. In addition, mRNA-1647 will be evaluated in female partici...
What is the current status of trial NCT05575492?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 873 participants. The study started on 2022-11-07. Estimated completion is 2027-01-15.
What conditions does trial NCT05575492 study?
This clinical trial studies the following conditions: Cytomegalovirus. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05575492?
The interventions under investigation include: Placebo (OTHER), mRNA-1647 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05575492?
This trial is sponsored by ModernaTX, which has 67 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05575492 being conducted?
This trial has 20 study locations across California, Colorado, District of Columbia, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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