Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05330078 · ClinicalTrials.gov registry record · Early Phase 1
Examining the Therapeutic Potential of Botulinum Toxin Type A in the Treatment of Keloids
A Early Phase 1 study of Keloid, sponsored by University of California, San Diego.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT05330078: Completed Early Phase 1 study of Keloid, sponsored by University of California, San Diego.
NCT05330078 is a Early Phase 1 study of Keloid that has completed, run by University of California, San Diego. The registered enrollment target is 10 participants, below the 2,143-participant average among 8 other Keloid trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05330078, a Early Phase 1 study of Keloid, has completed, sponsored by University of California, San Diego.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
Keloids are a common form of hypertrophic scars that by definition last beyond 6 months and grow beyond the site of initial injury. Keloids are a common complaint from patients in dermatology and cause significant functional impairment due to cosmetic disfigurement, itching and pain. Current treatment modalities include intralesional corticosteroids, chemotherapeutic agents and laser therapy. Initial reports have demonstrated that Botulinum toxin type A may be a viable treatment option for keloids that can reduce keloid size and reduce associated symptoms while having fewer side effects when compared to intralesional corticosteroid injection, which can cause unnatural blood vessel growth or skin thinning. To date, no study has carefully examined the efficacy of Botulinum toxin type A in treating keloids or its mechanistic effects on keloid biology. Our aim in this study is to pursue a rigorous, randomized control trial to assess the potential use Botulinum toxin type A to treat keloids. Efficacy will be objectively be mentioned by change in keloid size after treatment, along with subjective measures of patient satisfaction and symptoms, and finally physician rated scores. Also, samples from three patients will be analyzed in the laboratory setting to determine the underlying molecular mechanism behind the effects of Botulinum toxin type A on keloid biology.
Primary Outcome
Keloid volume will be measured using the high resolution 3D imaging system (Cherry Imaging platform)
Conditions Studied
Interventions
- DRUG Botulinum toxin type A
- DRUG Vehicle
Study Locations (1)
California
- University of California San Diego - San Diego
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2022-03-11 |
| Est. Completion | 2023-05-31 |
| Phase | Early Phase 1 |
What the finished NCT05330078 record still lists
NCT05330078 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 2,143-participant average among 8 other Keloid trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Keloid appearing as the primary indexed condition, and to 2 interventions - of which Botulinum toxin type A is the first listed.
NCT05330078 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05330078 about?
NCT05330078 is a clinical study titled "Examining the Therapeutic Potential of Botulinum Toxin Type A in the Treatment of Keloids". Keloids are a common form of hypertrophic scars that by definition last beyond 6 months and grow beyond the site of initial injury. Keloids are a common complaint from patients in dermatology and cause significant functional impairment due to cosmetic disfigurement, itching and pain. Current treatme...
What is the current status of trial NCT05330078?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 10 participants. The study started on 2022-03-11. Estimated completion is 2023-05-31.
What conditions does trial NCT05330078 study?
This clinical trial studies the following conditions: Keloid.
What interventions are being tested in trial NCT05330078?
The interventions under investigation include: Botulinum toxin type A (DRUG), Vehicle (DRUG).
Who is sponsoring clinical trial NCT05330078?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05330078 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Keloid
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05330078's enrollment target sits among peer trials
10 6th of 8 higher than 1 of 8 other Keloid trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Keloid trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
RAPA-Keloid Study of Keloid Regression
COMPLETED · Early Phase 1
-
Ritlecitinib in Patients With Keloids or Those Undergoing Keloidectomy
RECRUITING · Phase 2
-
Radiotherapy for Keloids
RECRUITING · NA
-
Genetic Analysis of Keloids
RECRUITING
-
Web Based Investigation of Natural History of Keloid Disorder, an Online Survey
RECRUITING
-
Pilot Study Investigating a Restorative Wound Care Cream Together With Petrolatum on Surgical Excisions
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00623389 · 10 participants · NA
Evaluation of an Advanced Lower Extremity Neuroprostheses
- NCT01241864 · 10 participants · Phase 2
Islet Transplantation in Type 1 Diabetic Kidney Allograft
- NCT01293214 · 10 participants · NA
Vascularized Composite Allotransplantation for Multiple Extremity Amputations
- NCT01474148 · 10 participants · NA
A Neuroprosthesis for Seated Posture and Balance
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI