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ACTIVE NOT RECRUITING Phase 3

Descemet Endothelial Thickness Comparison Trial I

NCT05289661 · View on ClinicalTrials.gov ↗

Study Summary

Descemet Endothelial Thickness Comparison Trial (DETECT) I is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 160 patients in a 2x2 factorial design. The purpose of this study is to determine differences in visual outcomes between two types of corneal transplant surgeries, ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet membrane endothelial keratoplasty (DMEK), and to determine the effect of rho-kinase inhibitors on endothelial cell loss.

Conditions Studied

Interventions

  • DRUG Topical Ripasudil
  • DRUG Topical Placebo

Study Locations (7)

California

  • Stanford University — Palo Alto
  • University of California Davis — Sacramento

Pennsylvania

  • University of Pennsylvania — Philadelphia
  • Wills Eye Hospital — Philadelphia

Florida

  • University of Miami — Palm Beach Gardens

New Hampshire

  • Dartmouth-Hitchcock Medical Center — Lebanon

Oregon

  • Oregon Health & Science University — Portland

Trial Details

FieldValue
Enrollment Target 160 participants
Start Date 2022-07-15
Est. Completion 2027-11-30
Phase Phase 3

Sponsor

Stanford University

1,643 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05289661

The ClinicalTrials.gov registry entry for NCT05289661 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 160 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Stanford University, which has 1,643 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Fuchs appearing as the primary indexed condition, and to 2 interventions — of which Topical Ripasudil is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05289661 reports 7 study locations spanning 5 distinct geographic areas — top geographies include California, Pennsylvania, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05289661 about?

NCT05289661 is a clinical study titled "Descemet Endothelial Thickness Comparison Trial I". Descemet Endothelial Thickness Comparison Trial (DETECT) I is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 160 patients in a 2x2 factorial design. The purpose of this study is to determine differences in visual outcomes between two types of corneal transplan...

What is the current status of trial NCT05289661?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 160 participants. The study started on 2022-07-15. Estimated completion is 2027-11-30.

What conditions does trial NCT05289661 study?

This clinical trial studies the following conditions: Fuchs. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05289661?

The interventions under investigation include: Topical Ripasudil (DRUG), Topical Placebo (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05289661?

This trial is sponsored by Stanford University, which has 1,643 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05289661 being conducted?

This trial has 7 study locations across California, Florida, New Hampshire, Oregon, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial