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RECRUITING Phase 1

Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology

NCT05184569 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of the study is to test the safety and tolerability of twice daily Verdiperstat in patients with semantic variant primary progressive aphasia (svPPA) due to frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Three-fourths of the participants will receive Verdiperstat and one-fourth will receive Placebo during the 24-week treatment duration.

Conditions Studied

Interventions

  • DRUG Verdiperstat

Study Locations (5)

California

  • UCSF Memory and Aging Center — San Francisco

Illinois

  • Northwestern University — Chicago

Minnesota

  • Mayo Clinic — Rochester

Pennsylvania

  • University of Pennsylvania — Philadelphia

Texas

  • Houston Methodist Hospital - Nantz National Alzheimer Center — Houston

Trial Details

FieldValue
Enrollment Target 64 participants
Start Date 2022-04-14
Est. Completion 2026-09-30
Phase Phase 1

Sponsor

Peter Ljubenkov, MD

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05184569

The ClinicalTrials.gov registry entry for NCT05184569 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 64 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Peter Ljubenkov, MD, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Semantic Dementia appearing as the primary indexed condition, and to 1 intervention — of which Verdiperstat is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05184569 reports 5 study locations spanning 5 distinct geographic areas — top geographies include California, Illinois, Minnesota. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05184569 about?

NCT05184569 is a clinical study titled "Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology". The purpose of the study is to test the safety and tolerability of twice daily Verdiperstat in patients with semantic variant primary progressive aphasia (svPPA) due to frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Three-fourths of the participants will receive Verdiperstat and...

What is the current status of trial NCT05184569?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 64 participants. The study started on 2022-04-14. Estimated completion is 2026-09-30.

What conditions does trial NCT05184569 study?

This clinical trial studies the following conditions: Semantic Dementia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05184569?

The interventions under investigation include: Verdiperstat (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05184569?

This trial is sponsored by Peter Ljubenkov, MD, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05184569 being conducted?

This trial has 5 study locations across California, Illinois, Minnesota, Pennsylvania, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial