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NCT05147831 · ClinicalTrials.gov registry record · NA
Effectiveness of Remote Ischemic Preconditioning for Prevention of Contrast Induced Acute Kidney Injury in Patients Undergoing Coronary Angiograms.
A NA study of Contrast-induced Acute Kidney Injury (CI-AKI) Following Coronary Angiogram (CI-AKI) and Contrast-induced Nephropathy Following Coronary Angiogram (CIN), sponsored by The University of Texas Medical Branch, Galveston.
- Recruiting
- Registry status
- NA
- Development phase
- 300
- Enrollment target
- 1
- Study location
NCT05147831 is a NA study of Contrast-induced Acute Kidney Injury (CI-AKI) Following Coronary Angiogram (CI-AKI) and Contrast-induced Nephropathy Following Coronary Angiogram (CIN) that is actively recruiting participants, run by The University of Texas Medical Branch, Galveston. The registered enrollment target is 300 participants. The trial reports 1 study location across 1 state.
The verdict
NCT05147831, a NA study of Contrast-induced Acute Kidney Injury (CI-AKI) Following Coronary Angiogram (CI-AKI) and Contrast-induced Nephropathy Following Coronary Angiogram (CIN), is actively recruiting participants, sponsored by The University of Texas Medical Branch, Galveston.
- RECRUITING
- Registry status
- NA
- Development phase
- 300 participants
- Enrollment target
- 1
- Study location
Study Summary
The use of imaging is increasing in clinical practice, either for diagnosis or intervention. In these imaging processes, contrast medium (CM) is widely used. However, CM administration can induce contrast-induced nephropathy (CI-AKI). CI-AKI is the third most common cause of renal insufficiency, and its incidence varies from 2% to 50% depending on patient risk factors; in addition, studies have shown that CI-AKI occurs in 2% to 25% of patients undergoing coronary intervention. CI-AKI is associated with significant mortality and morbidity in patients undergoing coronary angiography or other diagnostic contrast studies. We assessed the latest promising evidence on the ability of remote ischemic preconditioning (RIPC) to reduce the incidence of CI-AKI in patients undergoing Coronary Angiogram (CA) or diagnostic contrast studies such as CT angiogram, while at the same time being a non-invasive, low cost, easy, and safe method with absence of adverse effects. However, more randomized controlled trials are needed to confirm these preliminary results. The aim of this study is to minimize the incidence of CI-AKI at the University of Texas Medical Branch (UTMB). If found to be an effective method, RIPC would help minimize the incidence of CI-AKI in all institutions across the globe, who would adopt this intervention. The primary objective: i) reduce the rise in creatinine to \< 0.5 mg/dL post-CA in moderate to high risk patients and ii) reduce the incidence of renal replacement therapy post-CA in moderate to high risk patients; iii) we also aim to establish that RIPC is safe and effective. We hypothesize that the use of RIPC, when added to standard medical therapy (pre-and post-CA hydration), will mitigate the effects of contrast on the renal vasculature and lessen the incidence of CI-AKI in moderate to high risk patients at the University of Texas Medical Branch. The use of iodinated contrast to visually enhance target vasculature is a widely used diagnostic technique t
Conditions Studied
Interventions
- OTHER Remote Ischemic Preconditioning
Study Locations (1)
Texas
- University of Texas- Medical Branch (UTMB) - Galveston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2021-11-30 |
| Est. Completion | 2027-11-30 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05147831
The ClinicalTrials.gov registry entry for NCT05147831 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 300 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is The University of Texas Medical Branch, Galveston, which has 203 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Contrast-induced Acute Kidney Injury (CI-AKI) Following Coronary Angiogram (CI-AKI) appearing as the primary indexed condition, and to 1 intervention - of which Remote Ischemic Preconditioning is the first listed.
NCT05147831 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.
Frequently Asked Questions
What is clinical trial NCT05147831 about?
NCT05147831 is a clinical study titled "Effectiveness of Remote Ischemic Preconditioning for Prevention of Contrast Induced Acute Kidney Injury in Patients Undergoing Coronary Angiograms.". The use of imaging is increasing in clinical practice, either for diagnosis or intervention. In these imaging processes, contrast medium (CM) is widely used. However, CM administration can induce contrast-induced nephropathy (CI-AKI). CI-AKI is the third most common cause of renal insufficiency, and...
What is the current status of trial NCT05147831?
This trial is currently recruiting. It is a NA study. The enrollment target is 300 participants. The study started on 2021-11-30. Estimated completion is 2027-11-30.
What conditions does trial NCT05147831 study?
This clinical trial studies the following conditions: Contrast-induced Acute Kidney Injury (CI-AKI) Following Coronary Angiogram (CI-AKI), Contrast-induced Nephropathy Following Coronary Angiogram (CIN).
What interventions are being tested in trial NCT05147831?
The interventions under investigation include: Remote Ischemic Preconditioning (OTHER).
Who is sponsoring clinical trial NCT05147831?
This trial is sponsored by The University of Texas Medical Branch, Galveston, which has 203 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05147831 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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