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NCT05108623 · ClinicalTrials.gov registry record · Phase 1
A Study Investigating agenT-797 in Participants With Relapsed/Refractory Solid Tumors
A Phase 1 study of Tumor, Solid, sponsored by MiNK Therapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 34
- Enrollment target
- 8
- Study locations
NCT05108623 is a Phase 1 study of Tumor, Solid that has completed, run by MiNK Therapeutics. The registered enrollment target is 34 participants, below the 240-participant average among 11 other Tumor, Solid trials with a reported enrollment target (86% lower). The trial reports 8 study locations across 8 states.
The verdict
NCT05108623, a Phase 1 study of Tumor, Solid, has completed, sponsored by MiNK Therapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 34 participants
- Enrollment target
- 8
- Study locations
Study Summary
This is a Phase 1, open-label study to explore the safety, tolerability, and preliminary clinical activity of agenT-797, an unmodified, allogeneic iNKT cell therapy, in participants with relapsed/refractory (r/r) solid tumors, as well as define the recommended phase II dose in solid tumors. This Phase 1 study will also explore the safety, tolerability, and preliminary clinical activity of agenT-797 in combination with approved immune checkpoint inhibitors (ICIs), including pembrolizumab and nivolumab, in participants with r/r solid tumors.
Conditions Studied
Interventions
- DRUG agenT-797
- DRUG Approved ICIs
Study Locations (8)
California
- University of Southern California - Los Angeles
Colorado
- University of Colorado - Aurora
Kentucky
- Norton Cancer Health - Louisville
Massachusetts
- Beth Israel Deaconess Medical Center - Boston
Ohio
- University of Cincinnati Cancer Center - Cincinnati
Oregon
- Providence Portland Medical Center - Portland
Rhode Island
- LifeSpan - Rhode Island Hospital - Providence
Tennessee
- Sarah Cannon Research Institute - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2022-01-28 |
| Est. Completion | 2024-01-02 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05108623
The ClinicalTrials.gov registry entry for NCT05108623 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 34 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 240-participant average among 11 other Tumor, Solid trials with a reported enrollment target (86% lower). The listed sponsor is MiNK Therapeutics, which has 4 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Tumor, Solid appearing as the primary indexed condition, and to 2 interventions - of which agenT-797 is the first listed.
NCT05108623 reports 8 study locations spanning 8 distinct geographic areas - top geographies include California, Colorado, Kentucky.
Frequently Asked Questions
What is clinical trial NCT05108623 about?
NCT05108623 is a clinical study titled "A Study Investigating agenT-797 in Participants With Relapsed/Refractory Solid Tumors". This is a Phase 1, open-label study to explore the safety, tolerability, and preliminary clinical activity of agenT-797, an unmodified, allogeneic iNKT cell therapy, in participants with relapsed/refractory (r/r) solid tumors, as well as define the recommended phase II dose in solid tumors. This Pha...
What is the current status of trial NCT05108623?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 34 participants. The study started on 2022-01-28. Estimated completion is 2024-01-02.
What conditions does trial NCT05108623 study?
This clinical trial studies the following conditions: Tumor, Solid.
What interventions are being tested in trial NCT05108623?
The interventions under investigation include: agenT-797 (DRUG), Approved ICIs (DRUG).
Who is sponsoring clinical trial NCT05108623?
This trial is sponsored by MiNK Therapeutics, which has 4 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05108623 being conducted?
This trial has 8 study locations across California, Colorado, Kentucky, Massachusetts, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.