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COMPLETED Phase 1

A Study Investigating agenT-797 in Participants With Relapsed/Refractory Solid Tumors

NCT05108623 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase 1, open-label study to explore the safety, tolerability, and preliminary clinical activity of agenT-797, an unmodified, allogeneic iNKT cell therapy, in participants with relapsed/refractory (r/r) solid tumors, as well as define the recommended phase II dose in solid tumors. This Phase 1 study will also explore the safety, tolerability, and preliminary clinical activity of agenT-797 in combination with approved immune checkpoint inhibitors (ICIs), including pembrolizumab and nivolumab, in participants with r/r solid tumors.

Conditions Studied

Interventions

  • DRUG agenT-797
  • DRUG Approved ICIs

Study Locations (8)

California

  • University of Southern California — Los Angeles

Colorado

  • University of Colorado — Aurora

Kentucky

  • Norton Cancer Health — Louisville

Massachusetts

  • Beth Israel Deaconess Medical Center — Boston

Ohio

  • University of Cincinnati Cancer Center — Cincinnati

Oregon

  • Providence Portland Medical Center — Portland

Rhode Island

  • LifeSpan - Rhode Island Hospital — Providence

Tennessee

  • Sarah Cannon Research Institute — Nashville

Trial Details

FieldValue
Enrollment Target 34 participants
Start Date 2022-01-28
Est. Completion 2024-01-02
Phase Phase 1

Sponsor

MiNK Therapeutics

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05108623

The ClinicalTrials.gov registry entry for NCT05108623 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 34 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is MiNK Therapeutics, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Tumor, Solid appearing as the primary indexed condition, and to 2 interventions — of which agenT-797 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05108623 reports 8 study locations spanning 8 distinct geographic areas — top geographies include California, Colorado, Kentucky. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05108623 about?

NCT05108623 is a clinical study titled "A Study Investigating agenT-797 in Participants With Relapsed/Refractory Solid Tumors". This is a Phase 1, open-label study to explore the safety, tolerability, and preliminary clinical activity of agenT-797, an unmodified, allogeneic iNKT cell therapy, in participants with relapsed/refractory (r/r) solid tumors, as well as define the recommended phase II dose in solid tumors. This Pha...

What is the current status of trial NCT05108623?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 34 participants. The study started on 2022-01-28. Estimated completion is 2024-01-02.

What conditions does trial NCT05108623 study?

This clinical trial studies the following conditions: Tumor, Solid. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05108623?

The interventions under investigation include: agenT-797 (DRUG), Approved ICIs (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05108623?

This trial is sponsored by MiNK Therapeutics, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05108623 being conducted?

This trial has 8 study locations across California, Colorado, Kentucky, Massachusetts, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial