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ACTIVE NOT RECRUITING Phase 1

A Study of AMG 193 in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)

NCT05094336 · View on ClinicalTrials.gov ↗

Study Summary

The primary objective of Parts 1 and 2 of this study is to evaluate the safety, tolerability, and to determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D) of AMG 193 alone and in combination with docetaxel in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-null solid tumors. The primary objective of Part 3 of this study is to evaluate the efficacy of AMG 193 in adult participants with metastatic or locally advanced MTAP-null solid tumors.

Interventions

  • DRUG Docetaxel
  • DRUG AMG 193
  • DRUG Comparator AMG 193 Test Tablet

Study Locations (20)

California

  • City of Hope National Medical Center — Duarte
  • California Research Institute — Glendale
  • Fomat Medical Research — Oxnard
  • University of California at SF — San Francisco

Indiana

  • Goshen Health Systems — Goshen
  • Indiana University — Indianapolis
  • Community Health Network MD Anderson Cancer Center - North — Indianapolis

New York

  • Roswell Park Cancer Institute — Buffalo
  • Northwell Health Monter Cancer Center — Lake Success
  • New York University Grossman School of Medicine and New York University Langone Hospitals — New York

Florida

  • D and H Cancer Research Center — Margate
  • Boca Raton Clinical Research Medical Center Inc — Tamarac

Maryland

  • University of Maryland Medical Center — Baltimore
  • American Oncology Partners, PA — Bethesda

Michigan

  • Henry Ford Cancer Detroit (Brigitte Harris Cancer Pavilion) — Detroit

Missouri

  • Washington University — St Louis

New Jersey

  • Rutgers Cancer Institute of New Jersey — New Brunswick

Trial Details

FieldValue
Enrollment Target 329 participants
Start Date 2022-02-01
Est. Completion 2028-05-30
Phase Phase 1

Sponsor

Amgen

266 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05094336

The ClinicalTrials.gov registry entry for NCT05094336 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 329 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Amgen, which has 266 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Advanced MTAP-null Solid Tumors appearing as the primary indexed condition, and to 3 interventions — of which Docetaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05094336 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, Indiana, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05094336 about?

NCT05094336 is a clinical study titled "A Study of AMG 193 in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)". The primary objective of Parts 1 and 2 of this study is to evaluate the safety, tolerability, and to determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D) of AMG 193 alone and in combination with docetaxel in adult participants with metastatic or locally advanced methylthioad...

What is the current status of trial NCT05094336?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 329 participants. The study started on 2022-02-01. Estimated completion is 2028-05-30.

What conditions does trial NCT05094336 study?

This clinical trial studies the following conditions: Advanced MTAP-null Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05094336?

The interventions under investigation include: Docetaxel (DRUG), AMG 193 (DRUG), Comparator AMG 193 Test Tablet (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05094336?

This trial is sponsored by Amgen, which has 266 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05094336 being conducted?

This trial has 20 study locations across California, Florida, Indiana, Maryland, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial