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NCT05019456 · ClinicalTrials.gov registry record · NA
Exercise and COVID-19 Viral T-cell Immunity
A NA study of Influenza and COVID-19 Respiratory Infection, sponsored by University of Arizona.
- Active
- Registry status
- NA
- Development phase
- 26
- Enrollment target
- 1
- Study location
NCT05019456: Active NA study of Influenza and COVID-19 Respiratory Infection, sponsored by University of Arizona.
NCT05019456 is a NA study of Influenza and COVID-19 Respiratory Infection that is active but no longer recruiting, run by University of Arizona. The registered enrollment target is 26 participants, below the 36,804-participant average among 156 other Influenza trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05019456, a NA study of Influenza and COVID-19 Respiratory Infection, is active but no longer recruiting, sponsored by University of Arizona.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 26 participants
- Enrollment target
- 1
- Study location
Study Summary
Viruses are a major health problem for the general public and at risk populations. Normally, detection of antibody titers is the gold standard for determining the effectiveness of the immune system following natural or vaccine caused immunization. However, determining the effectiveness of other parts of the immune system are less common due to the difficulties with testing. Furthermore, there is a critical need to address other therapies in case vaccination is not successful in immuncompromised populations. Exercise has been shown to increase the strength of the immune system against many types of viruses and therefore could be simple way to improve immunity against the COVID-19 virus. The aim of this research is to determine the effects of exercise on anti-viral immunity against many types of common viruses before and after vaccination. We hypothesize that exercise will enhance the anti-viral immunity before and after vaccination. Up to 30 healthy volunteers (age 18-44 years) will be recruited to participate in this study. For completion of Aim 1, three visits are needed totaling around 7 hours of the patient's time and for Aim 2, three visits are needed totaling around 4.5 hours of the patient's time. The initial visit will be for pre-screening and if deemed healthy enough to participate, an exercise test to determine the VO2 max of the participant will be conducted. The following visits will require a trained phlebotomist to insert an in-dwelling catheter and participants will undergo a 20-minute incremental exercise trial. Approximately 50mL of blood will be collected at four different timepoints: at rest, 60% VO2 max, 80% VO2 max, and 1-hr post-exercise. All four collected blood samples will be used to expand viral specific T-cells and compare IFN-γ rele
Primary Outcome
Determine the differences in IFN-γ concentrations via an ELISA
Conditions Studied
Interventions
- BIOLOGICAL COVID-19 Vaccine
Study Locations (1)
Arizona
- The University of Arizona - Tucson
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2021-03-09 |
| Est. Completion | 2025-12-25 |
| Phase | NA |
What the registry record for NCT05019456 still lists
NCT05019456 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 36,804-participant average among 156 other Influenza trials with a reported enrollment target (100% lower).
The record links to 2 conditions, with Influenza appearing as the primary indexed condition, and to 1 intervention - of which COVID-19 Vaccine is the first listed.
NCT05019456 reports a single indexed study location in Arizona.
Frequently Asked Questions
What is clinical trial NCT05019456 about?
NCT05019456 is a clinical study titled "Exercise and COVID-19 Viral T-cell Immunity". Viruses are a major health problem for the general public and at risk populations. Normally, detection of antibody titers is the gold standard for determining the effectiveness of the immune system following natural or vaccine caused immunization. However, determining the effectiveness of other part...
What is the current status of trial NCT05019456?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 26 participants. The study started on 2021-03-09. Estimated completion is 2025-12-25.
What conditions does trial NCT05019456 study?
This clinical trial studies the following conditions: Influenza, COVID-19 Respiratory Infection.
What interventions are being tested in trial NCT05019456?
The interventions under investigation include: COVID-19 Vaccine (BIOLOGICAL).
Who is sponsoring clinical trial NCT05019456?
This trial is sponsored by University of Arizona, which has 349 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05019456 being conducted?
This trial has 1 study location across Arizona. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05019456's enrollment target sits among peer trials
26 146th of 156 higher than 11 of 156 other Influenza trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Influenza trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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