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NCT04992780 · ClinicalTrials.gov registry record · Phase 2
Comparing Hypo-fractionated Intensity- Modulated Radiation Therapy to Standard- Fractionated IMRT Along With Chemotherapy and Immunotherapy for Non-Small Cell Lung Cancer
A Phase 2 study of Non Small Cell Lung Cancer Stage, sponsored by University of Kansas Medical Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 50
- Enrollment target
- 6
- Study locations
NCT04992780 is a Phase 2 study of Non Small Cell Lung Cancer Stage that is actively recruiting participants, run by University of Kansas Medical Center. The registered enrollment target is 50 participants. The trial reports 6 study locations across 2 states.
The verdict
NCT04992780, a Phase 2 study of Non Small Cell Lung Cancer Stage, is actively recruiting participants, sponsored by University of Kansas Medical Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 50 participants
- Enrollment target
- 6
- Study locations
Study Summary
The hypothesis for this study is that hypofractionated IMRT to 62.5 Gy in 25 fractions (2.5 Gy/fraction) with concurrent carboplatin and paclitaxel, followed by maintenance durvalumab will improve locoregional control at 18 months by 10% compared to standard-fractionated chemo-IMRT/durvalumab. A modest improvement in locoregional control (LRC) was selected as a target which could merit further study of this hypofractionated IMRT regimen in a Phase III trial
Conditions Studied
Interventions
- RADIATION Hypo-Fractionation
- RADIATION Standard-Fractionation
Study Locations (6)
Kansas
- The University of Kansas Cancer Center, Westwood Campus - Kansas City
- The University of Kansas Cancer Center, Overland Park Clinic - Overland Park
- KUCC MCA- TUKHS, Saint Francis Hospital - Topeka
Missouri
- The University of Kansas Cancer Center, North Clinic - Kansas City
- The University of Kansas Cancer Center, Lee's Summit Clinic - Lee's Summit
- University of Kansas Cancer Center, North Kansas City Hospital - North Kansas City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2022-02-25 |
| Est. Completion | 2026-11 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04992780
The ClinicalTrials.gov registry entry for NCT04992780 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Kansas Medical Center, which has 408 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Non Small Cell Lung Cancer Stage appearing as the primary indexed condition, and to 2 interventions - of which Hypo-Fractionation is the first listed.
NCT04992780 reports 6 study locations spanning 2 distinct geographic areas - top geographies include Kansas, Missouri.
Frequently Asked Questions
What is clinical trial NCT04992780 about?
NCT04992780 is a clinical study titled "Comparing Hypo-fractionated Intensity- Modulated Radiation Therapy to Standard- Fractionated IMRT Along With Chemotherapy and Immunotherapy for Non-Small Cell Lung Cancer". The hypothesis for this study is that hypofractionated IMRT to 62.5 Gy in 25 fractions (2.5 Gy/fraction) with concurrent carboplatin and paclitaxel, followed by maintenance durvalumab will improve locoregional control at 18 months by 10% compared to standard-fractionated chemo-IMRT/durvalumab. A mod...
What is the current status of trial NCT04992780?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 50 participants. The study started on 2022-02-25. Estimated completion is 2026-11.
What conditions does trial NCT04992780 study?
This clinical trial studies the following conditions: Non Small Cell Lung Cancer Stage.
What interventions are being tested in trial NCT04992780?
The interventions under investigation include: Hypo-Fractionation (RADIATION), Standard-Fractionation (RADIATION).
Who is sponsoring clinical trial NCT04992780?
This trial is sponsored by University of Kansas Medical Center, which has 408 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04992780 being conducted?
This trial has 6 study locations across Kansas, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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