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DPX-Survivac and Pembrolizumab With and Without Intermittent Low-Dose Cyclophosphamide, in Subjects With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
NCT04920617 · View on ClinicalTrials.gov ↗
Study Summary
This is a Phase 2b, randomized, open label study to assess the safety and efficacy of DPX-Survivac and pembrolizumab, with and without low-dose cyclophosphamide (CPA) in subjects with relapsed or refractory DLBCL.
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG DPX-Survivac
- DRUG CPA
Study Locations (20)
Florida
- Boca Raton Regional Hospital — Boca Raton
- BRCR Medical Center Inc. — Hollywood
- BRCR Medical Center Inc. — Plantation
- Comprehensive Hematology and Oncology — St. Petersburg
Ohio
- Gabrail Cancer Center Research — Canton
- University of Toledo Medical Center — Toledo
- Toledo Clinic Cancer Center — Toledo
Pennsylvania
- Allegheny Health Network (AHN) West Penn Hospital — Pittsburgh
- Reading Hospital - McGlinn Cancer Institute — West Reading
Victoria
- Epworth Freemasons Hospital — Melbourne
- Box Hill Hospital — Melbourne
California
- Compassionate Cancer Care Medical Group — Fountain Valley
Georgia
- Blood and Marrow Transplant Group of Georgia — Atlanta
Indiana
- Indiana University Health Melvin and Bren Simon Cancer Center — Indianapolis
Louisiana
- Tulane Cancer Center Office of Clinical Research — New Orleans
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 102 participants |
| Start Date | 2021-06-18 |
| Est. Completion | 2025-04 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04920617
The ClinicalTrials.gov registry entry for NCT04920617 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 102 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ImmunoVaccine Technologies, Inc. (IMV Inc.), which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Refractory Diffuse Large B-cell Lymphoma appearing as the primary indexed condition, and to 3 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04920617 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Florida, Ohio, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04920617 about?
NCT04920617 is a clinical study titled "DPX-Survivac and Pembrolizumab With and Without Intermittent Low-Dose Cyclophosphamide, in Subjects With Relapsed/Refractory Diffuse Large B-Cell Lymphoma". This is a Phase 2b, randomized, open label study to assess the safety and efficacy of DPX-Survivac and pembrolizumab, with and without low-dose cyclophosphamide (CPA) in subjects with relapsed or refractory DLBCL.
What is the current status of trial NCT04920617?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 102 participants. The study started on 2021-06-18. Estimated completion is 2025-04.
What conditions does trial NCT04920617 study?
This clinical trial studies the following conditions: Refractory Diffuse Large B-cell Lymphoma, Relapsed Diffuse Large B-cell Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04920617?
The interventions under investigation include: Pembrolizumab (DRUG), DPX-Survivac (DRUG), CPA (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04920617?
This trial is sponsored by ImmunoVaccine Technologies, Inc. (IMV Inc.), which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04920617 being conducted?
This trial has 20 study locations across California, Florida, Georgia, Indiana, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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