Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma
NCT04910568 · View on ClinicalTrials.gov ↗
Study Summary
This Phase Ib, multicenter, open-label study will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of cevostamab monotherapy, cevostamab plus pomalidomide and dexamethasone (Pd) or cevostamab plus daratumumab and dexamethasone (Dd) which will be administered to participants with relapsed or refractory multiple myeloma (R/R MM) via intravenous (IV) infusion.
Conditions Studied
Interventions
- DRUG Dexamethasone
- DRUG Daratumumab
- DRUG Pomalidomide
- DRUG Tocilizumab
- DRUG Cevostamab
Study Locations (20)
Other
- Fakultni Nemocnice Ostrava — Ostrava
- Rigshospitalet — København Ø
- Hôpital Saint-Louis — Paris
- CHU de Poitiers - La Miletrie — Poitiers
- Rambam Medical Center — Haifa
- Yamagata University Hospital — Yamagata
- Pratia Onkologia Katowice — Katowice
- Uniwersytecki Szpital Kliniczny w Poznaniu — Późna
California
- City of Hope — Duarte
- City of Hope - Lennar Foundation Cancer Center — Irvine
Victoria
- Peter MacCallum Cancer Centre — Melbourne
- The Alfred Hospital — Melbourne
Ontario
- Hamilton Health Sciences — Hamilton
- University Health Network — Toronto
Lombardy
- Asst Papa Giovanni Xxiii — Bergamo
- A.O. Spedali Civili Di Brescia-P.O. Spedali Civili — Brescia
Colorado
- Colorado Blood Cancer Institute (CBCI) at Presbyterian/ St. Luke's Medical Center — Denver
Michigan
- Karmanos Cancer Institute. — Detroit
Missouri
- Washington University School of Medicine — St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 126 participants |
| Start Date | 2021-07-26 |
| Est. Completion | 2029-12-10 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04910568
The ClinicalTrials.gov registry entry for NCT04910568 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 126 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genentech, which has 206 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions — of which Dexamethasone is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04910568 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Other, California, Victoria. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04910568 about?
NCT04910568 is a clinical study titled "A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma". This Phase Ib, multicenter, open-label study will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of cevostamab monotherapy, cevostamab plus pomalidomide and dexamethasone (Pd) or cevostamab plus daratumumab and dexamethasone (Dd) which will be administered to par...
What is the current status of trial NCT04910568?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 126 participants. The study started on 2021-07-26. Estimated completion is 2029-12-10.
What conditions does trial NCT04910568 study?
This clinical trial studies the following conditions: Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04910568?
The interventions under investigation include: Dexamethasone (DRUG), Daratumumab (DRUG), Pomalidomide (DRUG), Tocilizumab (DRUG), Cevostamab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04910568?
This trial is sponsored by Genentech, which has 206 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04910568 being conducted?
This trial has 20 study locations across California, Colorado, Michigan, Missouri, Victoria. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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