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Tumor-induced Osteomalacia Disease Monitoring Program
NCT04783428 · View on ClinicalTrials.gov ↗
Study Summary
The objectives of this observational study are to assess the long-term safety and long-term effectiveness of burosumab in patients with TIO who are being treated with burosumab as prescribed by their physician and to monitor the course of the underlying phosphaturic mesenchymal tumor (PMT) overtime in patients with TIO irrespective of their treatment status.
Conditions Studied
Interventions
- OTHER No intervention
Study Locations (6)
Connecticut
- Yale University — New Haven
Indiana
- Indiana University — Bloomington
Maryland
- Johns Hopkins University — Baltimore
Tennessee
- Vanderbilt University Medical Center — Nashville
Virginia
- University of Virginia — Charlottesville
Other
- IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas — Buenos Aires
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 23 participants |
| Start Date | 2022-01-31 |
| Est. Completion | 2032-02-28 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04783428
The ClinicalTrials.gov registry entry for NCT04783428 describes a study currently listed as active not recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 23 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Ultragenyx Pharmaceutical, which has 23 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Tumor-induced Osteomalacia (TIO) appearing as the primary indexed condition, and to 1 intervention — of which No intervention is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04783428 reports 6 study locations spanning 6 distinct geographic areas — top geographies include Connecticut, Indiana, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04783428 about?
NCT04783428 is a clinical study titled "Tumor-induced Osteomalacia Disease Monitoring Program". The objectives of this observational study are to assess the long-term safety and long-term effectiveness of burosumab in patients with TIO who are being treated with burosumab as prescribed by their physician and to monitor the course of the underlying phosphaturic mesenchymal tumor (PMT) overtime ...
What is the current status of trial NCT04783428?
This trial is currently active not recruiting. The enrollment target is 23 participants. The study started on 2022-01-31. Estimated completion is 2032-02-28.
What conditions does trial NCT04783428 study?
This clinical trial studies the following conditions: Tumor-induced Osteomalacia (TIO). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04783428?
The interventions under investigation include: No intervention (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04783428?
This trial is sponsored by Ultragenyx Pharmaceutical, which has 23 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04783428 being conducted?
This trial has 6 study locations across Connecticut, Indiana, Maryland, Tennessee, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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