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ACTIVE NOT RECRUITING Phase 1

Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma

NCT04756726 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to characterize the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of oral cemsidomide (also known as CFT7455) administered at different dosages in subjects with Relapsed/Refractory (r/r) Non-Hodgkin's Lymphoma (NHL) or Multiple Myeloma (MM). Cemsidomide may be administered as a single agent and, in MM only, in combination with oral dexamethasone.

Interventions

  • DRUG Dexamethasone Oral
  • DRUG cemsidomide

Study Locations (13)

Massachusetts

  • Massachusetts General Hospital — Boston
  • Dana-Farber Cancer Institute — Boston

New York

  • Mt Sinai Medical Center — New York
  • Memorial Sloan Kettering Cancer Center — New York

Arizona

  • Mayo Clinic — Phoenix

California

  • University of California-San Francisco — San Francisco

Colorado

  • Colorado Blood Cancer Institute (Sarah Cannon Research Institute) — Denver

Florida

  • Mayo Clinic — Jacksonville

Georgia

  • Emory University Hospital — Atlanta

Minnesota

  • Mayo Clinic — Rochester

Trial Details

FieldValue
Enrollment Target 224 participants
Start Date 2021-04-27
Est. Completion 2026-03-31
Phase Phase 1

Sponsor

C4 Therapeutics

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04756726

The ClinicalTrials.gov registry entry for NCT04756726 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 224 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is C4 Therapeutics, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 2 interventions — of which Dexamethasone Oral is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04756726 reports 13 study locations spanning 11 distinct geographic areas — top geographies include Massachusetts, New York, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04756726 about?

NCT04756726 is a clinical study titled "Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma". The purpose of this study is to characterize the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of oral cemsidomide (also known as CFT7455) administered at different dosages in subjects with Relapsed/Refractory (r/r) Non-Hodgkin's Lymphoma (NHL) or Multiple Myeloma ...

What is the current status of trial NCT04756726?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 224 participants. The study started on 2021-04-27. Estimated completion is 2026-03-31.

What conditions does trial NCT04756726 study?

This clinical trial studies the following conditions: Multiple Myeloma, Lymphoma, Non-Hodgkin's. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04756726?

The interventions under investigation include: Dexamethasone Oral (DRUG), cemsidomide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04756726?

This trial is sponsored by C4 Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04756726 being conducted?

This trial has 13 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial