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NCT04414111 · ClinicalTrials.gov registry record

Highly Suppressive Treg in Delayed and Slow Graft Function After Kidney Transplantation

A clinical trial of Kidney Transplant; Complications and DGF, sponsored by St. Louis University.

Active
Registry status
180
Enrollment target
2
Study locations

NCT04414111 is a study of Kidney Transplant; Complications and DGF that is active but no longer recruiting, run by St. Louis University. The registered enrollment target is 180 participants, above the 112-participant average among 19 other Kidney Transplant; Complications trials with a reported enrollment target (61% higher). The trial reports 2 study locations across 2 states.

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The verdict

NCT04414111, a study of Kidney Transplant; Complications and DGF, is active but no longer recruiting, sponsored by St. Louis University.

ACTIVE NOT RECRUITING
Registry status
180 participants
Enrollment target
2
Study locations

Study Summary

Delayed/slow graft function is the most common complication after kidney transplantation with an incidence over 20% and is the result of ischemia-reperfusion injury. The increased use of marginal kidney grafts to palliate the organ shortage is leading to a continued rise in the incidence of delayed/slow graft function. Delayed/slow graft function, however, is associated with an increased risk of acute rejection and graft failure. There are currently no clinically accepted biomarkers and no specific treatments for delayed/slow graft function. Regulatory T cells are protective in ischemia-reperfusion injury and rejection by suppressing pathologic immune responses. We hypothesize that the pre-transplant measurement of highly suppressive regulatory T cell is an accurate biomarker for delayed/slow graft function and its immunologic consequences. Ultimately, marginal kidney graft allocation could be directed to regulatory T cell-robust recipients and regulatory T cell-directed therapies could decrease marginal kidney graft discards without increasing delayed/slow graft function or impacting outcomes.

Conditions Studied

Kidney Transplant; Complications DGF

Interventions

  • DIAGNOSTIC_TEST Highly suppressive Treg measurement

Study Locations (2)

California

  • Loma Linda University Health Transplantation Institute - San Bernardino

Missouri

  • Saint Louis University - St Louis

Trial Details

FieldValue
Enrollment Target 180 participants
Start Date 2020-12-07
Est. Completion 2027-07-31

Sponsor

St. Louis University

107 total trials

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What the Registry Record Tells You About NCT04414111

The ClinicalTrials.gov registry entry for NCT04414111 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 112-participant average among 19 other Kidney Transplant; Complications trials with a reported enrollment target (61% higher). The listed sponsor is St. Louis University, which has 107 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Kidney Transplant; Complications appearing as the primary indexed condition, and to 1 intervention - of which Highly suppressive Treg measurement is the first listed.

NCT04414111 reports 2 study locations spanning 2 distinct geographic areas - top geographies include California, Missouri.

Frequently Asked Questions

What is clinical trial NCT04414111 about?

NCT04414111 is a clinical study titled "Highly Suppressive Treg in Delayed and Slow Graft Function After Kidney Transplantation". Delayed/slow graft function is the most common complication after kidney transplantation with an incidence over 20% and is the result of ischemia-reperfusion injury. The increased use of marginal kidney grafts to palliate the organ shortage is leading to a continued rise in the incidence of delayed/...

What is the current status of trial NCT04414111?

This trial is currently active not recruiting. The enrollment target is 180 participants. The study started on 2020-12-07. Estimated completion is 2027-07-31.

What conditions does trial NCT04414111 study?

This clinical trial studies the following conditions: Kidney Transplant; Complications, DGF.

What interventions are being tested in trial NCT04414111?

The interventions under investigation include: Highly suppressive Treg measurement (DIAGNOSTIC_TEST).

Who is sponsoring clinical trial NCT04414111?

This trial is sponsored by St. Louis University, which has 107 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04414111 being conducted?

This trial has 2 study locations across California, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.