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ACTIVE NOT RECRUITING Phase 3

Platinum-Based Chemotherapy With/Without INCMGA00012, an Anti-PD-1 Antibody, in Non-Small Cell Lung Cancer

NCT04205812 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to assess the efficacy and safety of platinum-based chemotherapy with or without INCMGA00012 in participants with metastatic squamous and nonsquamous non-small cell lung cancer (NSCLC).

Interventions

  • DRUG Carboplatin
  • DRUG Placebo
  • DRUG Retifanlimab
  • DRUG Cisplatin
  • DRUG Pemetrexed

Study Locations (20)

Other

  • Fundacao Pio Xii Hospital de Cancer de Barretos — Barretos
  • Incan - Instituto Do Cancer - Hospital Pompeia — Caxias do Sul
  • Centro Regional Integrado de Oncologia — Fortaleza
  • Oncosite - Centro de Pesquisa Clinica E Oncologia — Ijuí
  • Clinica de Neoplasias Litoral Ltda — Itajaí
  • Hospital Do Cancer de Londrina — Londrina
  • Instituto Mederi de Pesquisa E Saude — Passo Fundo
  • Hgb - Hospital Giovanni Battista - Mae de Deus Center — Porto Alegre
  • Inca - Instituto Nacional de Cancer — Rio de Janeiro
  • Sao Camilo Oncologia — S?O Paulo
  • Cepho - Centro de Estudos E Pesquisas de Hematologia E Oncologia — Santo André
  • Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto — São José
  • Mc Women'S Health-Nadezhda Eood — Sofia
  • Acibadem Cityclinica Mhat Tokuda — Sofia
  • Umhat Sv. Ivan Rilski Ead — Sofia
  • Mhat Serdika Eood — Sofia
  • Multiprofile Hospital For Active Treatment Central Onco Hospital Ood — Sofia

California

  • Pacific Cancer Medical Center — Anaheim
  • Innovative Clinical Research Institute — Whittier

Pennsylvania

  • Reading Hospital and Medical Center — Reading

Trial Details

FieldValue
Enrollment Target 583 participants
Start Date 2020-09-11
Est. Completion 2026-08-28
Phase Phase 3

Sponsor

Incyte Corporation

163 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04205812

The ClinicalTrials.gov registry entry for NCT04205812 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 583 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Incyte Corporation, which has 163 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Metastatic Squamous Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04205812 reports 20 study locations spanning 3 distinct geographic areas — top geographies include Other, California, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04205812 about?

NCT04205812 is a clinical study titled "Platinum-Based Chemotherapy With/Without INCMGA00012, an Anti-PD-1 Antibody, in Non-Small Cell Lung Cancer". The purpose of this study is to assess the efficacy and safety of platinum-based chemotherapy with or without INCMGA00012 in participants with metastatic squamous and nonsquamous non-small cell lung cancer (NSCLC).

What is the current status of trial NCT04205812?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 583 participants. The study started on 2020-09-11. Estimated completion is 2026-08-28.

What conditions does trial NCT04205812 study?

This clinical trial studies the following conditions: Metastatic Squamous Non-Small Cell Lung Cancer, Metastatic Nonsquamous Non-Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04205812?

The interventions under investigation include: Carboplatin (DRUG), Placebo (DRUG), Retifanlimab (DRUG), Cisplatin (DRUG), Pemetrexed (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04205812?

This trial is sponsored by Incyte Corporation, which has 163 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04205812 being conducted?

This trial has 20 study locations across California, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial