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NCT04151901 · ClinicalTrials.gov registry record · NA
Sex-specific Determinants of Early-phase Recovery From Skeletal Muscle Disuse
A NA study of Rehabilitation and Atrophy of Muscle Due to Disuse, sponsored by The University of Texas Health Science Center at San Antonio.
- Recruiting
- Registry status
- NA
- Development phase
- 80
- Enrollment target
- 2
- Study locations
NCT04151901: Recruiting NA study of Rehabilitation and Atrophy of Muscle Due to Disuse, sponsored by The University of Texas Health Science Center at San Antonio.
NCT04151901 is a NA study of Rehabilitation and Atrophy of Muscle Due to Disuse that is actively recruiting participants, run by The University of Texas Health Science Center at San Antonio. The registered enrollment target is 80 participants, below the 160-participant average among 15 other Rehabilitation trials with a reported enrollment target (50% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04151901, a NA study of Rehabilitation and Atrophy of Muscle Due to Disuse, is actively recruiting participants, sponsored by The University of Texas Health Science Center at San Antonio.
- RECRUITING
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
- 2
- Study locations
Study Summary
This project is a 2-phase, randomized clinical trial that includes 7 days of unilateral leg disuse (Phase 1), immediately followed by 1 week of bilateral leg rehabilitation (Phase 2). The investigators will recruit cohorts of healthy middle-aged men and women to address their aims: * Demonstrate the sex-specific effects of skeletal muscle disuse (Phase 1) * Identify key molecular determinates of susceptibility of skeletal muscle atrophy (Phase 1) * Map the early, sex-specific molecular time-course of rehabilitation (Phase 2) * Determine if disused and healthy muscle respond similarly to exercise (Phase 2) Healthy, middle-age men and post-menopausal women (50-65 years) will be recruited from the greater Houston/Galveston area. This under-represented research demographic demonstrate few negative metabolic or phenotypic signs of advanced age, but are at increased risk of being hospitalized and experiencing accelerated loss of lean mass and muscle function that parallels a much older population. The goal of this study is to characterize phenotypic and molecular skeletal muscle changes in middle-aged men and women during critical periods of disuse and rehabilitation and ultimately direct the development of targeted and effective prevention and treatment strategies.
Primary Outcome
RNA deep sequence analysis on muscle tissue taken from a muscle biopsy to measure transcriptome
Conditions Studied
Interventions
- OTHER Resistance Exercise Rehabilitation
- OTHER Walking-based rehabilitation
Study Locations (2)
Texas
- University of Texas Medical Branch - Galveston
- University of Texas Health Science Center at San Antonio - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2021-08-27 |
| Est. Completion | 2026-12 |
| Phase | NA |
What NCT04151901 shows while recruiting
NCT04151901 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 160-participant average among 15 other Rehabilitation trials with a reported enrollment target (50% lower).
The record links to 2 conditions, with Rehabilitation appearing as the primary indexed condition, and to 2 interventions - of which Resistance Exercise Rehabilitation is the first listed.
NCT04151901 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT04151901 about?
NCT04151901 is a clinical study titled "Sex-specific Determinants of Early-phase Recovery From Skeletal Muscle Disuse". This project is a 2-phase, randomized clinical trial that includes 7 days of unilateral leg disuse (Phase 1), immediately followed by 1 week of bilateral leg rehabilitation (Phase 2). The investigators will recruit cohorts of healthy middle-aged men and women to address their aims: * Demonstrate th...
What is the current status of trial NCT04151901?
This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2021-08-27. Estimated completion is 2026-12.
What conditions does trial NCT04151901 study?
This clinical trial studies the following conditions: Rehabilitation, Atrophy of Muscle Due to Disuse.
What interventions are being tested in trial NCT04151901?
The interventions under investigation include: Resistance Exercise Rehabilitation (OTHER), Walking-based rehabilitation (OTHER).
Who is sponsoring clinical trial NCT04151901?
This trial is sponsored by The University of Texas Health Science Center at San Antonio, which has 378 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04151901 being conducted?
This trial has 2 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Rehabilitation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04151901's enrollment target sits among peer trials
80 9th of 15 higher than 7 of 15 other Rehabilitation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Rehabilitation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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