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ACTIVE NOT RECRUITING Phase 2

Platform Study of Belantamab Mafodotin as Monotherapy and in Combination With Anti-cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)

NCT04126200 · View on ClinicalTrials.gov ↗

Study Summary

B-cell maturation antigen (BCMA) is a target present on tumor cells in participants with multiple myeloma. Belantamab mafodotin (GSK2857916); is an antibody-drug conjugate (ADC) containing humanized anti-BCMA monoclonal antibody (mAb). This is a phase I/II, randomized, open-label, platform study designed to evaluate the effects of belantamab mafodotin in combination with other anti-cancer drugs in participants with relapsed/refractory multiple myeloma. The Platform design incorporates a single master protocol, where multiple treatment combinations, as sub-studies, will be evaluated simultaneously.

Conditions Studied

Interventions

  • DRUG Belantamab mafodotin
  • DRUG Nirogacestat
  • DRUG Dostarlimab
  • DRUG GSK3174998
  • DRUG Feladilimab

Study Locations (20)

Other

  • GSK Investigational Site — Porto Alegre
  • GSK Investigational Site — Salvador
  • GSK Investigational Site — São Paulo
  • GSK Investigational Site — Lille
  • GSK Investigational Site — Villejuif
  • GSK Investigational Site — Frankfurt
  • GSK Investigational Site — Hamburg
  • GSK Investigational Site — Kiel
  • GSK Investigational Site — Leipzig
  • GSK Investigational Site — Athens

Victoria

  • GSK Investigational Site — Fitzroy
  • GSK Investigational Site — Melbourne

Georgia

  • GSK Investigational Site — Atlanta

Indiana

  • GSK Investigational Site — Indianapolis

Massachusetts

  • GSK Investigational Site — Boston

Michigan

  • GSK Investigational Site — Grand Rapids

Wisconsin

  • GSK Investigational Site — Madison

British Columbia

  • GSK Investigational Site — Vancouver

Trial Details

FieldValue
Enrollment Target 208 participants
Start Date 2019-10-07
Est. Completion 2027-03-11
Phase Phase 2

Sponsor

GlaxoSmithKline

558 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04126200

The ClinicalTrials.gov registry entry for NCT04126200 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 208 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is GlaxoSmithKline, which has 558 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions — of which Belantamab mafodotin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04126200 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Other, Victoria, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04126200 about?

NCT04126200 is a clinical study titled "Platform Study of Belantamab Mafodotin as Monotherapy and in Combination With Anti-cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)". B-cell maturation antigen (BCMA) is a target present on tumor cells in participants with multiple myeloma. Belantamab mafodotin (GSK2857916); is an antibody-drug conjugate (ADC) containing humanized anti-BCMA monoclonal antibody (mAb). This is a phase I/II, randomized, open-label, platform study des...

What is the current status of trial NCT04126200?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 208 participants. The study started on 2019-10-07. Estimated completion is 2027-03-11.

What conditions does trial NCT04126200 study?

This clinical trial studies the following conditions: Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04126200?

The interventions under investigation include: Belantamab mafodotin (DRUG), Nirogacestat (DRUG), Dostarlimab (DRUG), GSK3174998 (DRUG), Feladilimab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04126200?

This trial is sponsored by GlaxoSmithKline, which has 558 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04126200 being conducted?

This trial has 20 study locations across Georgia, Indiana, Massachusetts, Michigan, Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial