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NCT03944954 · ClinicalTrials.gov registry record · Early Phase 1
Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults
A Early Phase 1 study of Substance-Related Disorders and Behavior Problem, sponsored by Michael J. Wesley, PhD.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 66
- Enrollment target
- 1
- Study location
NCT03944954: Completed Early Phase 1 study of Substance-Related Disorders and Behavior Problem, sponsored by Michael J. Wesley, PhD.
NCT03944954 is a Early Phase 1 study of Substance-Related Disorders and Behavior Problem that has completed, run by Michael J. Wesley, PhD. The registered enrollment target is 66 participants, below the 1,520-participant average among 58 other Substance-Related Disorders trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03944954, a Early Phase 1 study of Substance-Related Disorders and Behavior Problem, has completed, sponsored by Michael J. Wesley, PhD.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 66 participants
- Enrollment target
- 1
- Study location
Study Summary
Emerging adults are a particularly vulnerable group for experiencing the immediate and potentially lifelong negative impacts of habitual cannabis use, and trends suggest that cannabis use disorder (CUD) will soon escalate in this population. The proposed research will combine clinical pharmacology, non-invasive brain stimulation, and neuroimaging techniques to establish the brain mechanisms of cannabinoid-impaired decision-making processes in emerging adults with CUD. Results from this project will inform CUD prevention/treatment efforts in this high-risk group and address a growing public health concern.
Primary Outcome
In a Probabilistic Reinforcement Learning Choice (PRLC) task, two stimuli are presented and choosing either could result in a monetary reinforcer, but the reinforcement probabilities of the stimuli differ, and change throughout the task. Individuals attempt to optimize choices according to learned probabilities and track changing probabilities over time. PRLC performance allows mathematical modeling of trial-by-trial data under "real-world" uncertainty and yields computational parameters, such
Conditions Studied
Interventions
- DEVICE Placebo TMS Sham
- DRUG Marinol 10Mg Capsule TMS Sham
- DRUG Marinol 30Mg Capsule TMS Sham
- DEVICE Placebo TMS Real
- OTHER Marinol 10Mg Capsule TMS Real
Study Locations (1)
Kentucky
- Neurobehavioral Systems Lab of the University of Kentucky College of Medicine - Lexington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2017-07-15 |
| Est. Completion | 2023-12-13 |
| Phase | Early Phase 1 |
What the finished NCT03944954 record still lists
NCT03944954 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 66 participants, a relatively small participant target, below the 1,520-participant average among 58 other Substance-Related Disorders trials with a reported enrollment target (96% lower).
The record links to 3 conditions, with Substance-Related Disorders appearing as the primary indexed condition, and to 5 interventions - of which Placebo TMS Sham is the first listed.
NCT03944954 reports a single indexed study location in Kentucky.
Frequently Asked Questions
What is clinical trial NCT03944954 about?
NCT03944954 is a clinical study titled "Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults". Emerging adults are a particularly vulnerable group for experiencing the immediate and potentially lifelong negative impacts of habitual cannabis use, and trends suggest that cannabis use disorder (CUD) will soon escalate in this population. The proposed research will combine clinical pharmacology, ...
What is the current status of trial NCT03944954?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 66 participants. The study started on 2017-07-15. Estimated completion is 2023-12-13.
What conditions does trial NCT03944954 study?
This clinical trial studies the following conditions: Substance-Related Disorders, Behavior Problem, Neurosciences.
What interventions are being tested in trial NCT03944954?
The interventions under investigation include: Placebo TMS Sham (DEVICE), Marinol 10Mg Capsule TMS Sham (DRUG), Marinol 30Mg Capsule TMS Sham (DRUG), Placebo TMS Real (DEVICE), Marinol 10Mg Capsule TMS Real (OTHER).
Who is sponsoring clinical trial NCT03944954?
This trial is sponsored by Michael J. Wesley, PhD, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03944954 being conducted?
This trial has 1 study location across Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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