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COMPLETED Phase 3

A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (TENAYA)

NCT03823287 · View on ClinicalTrials.gov ↗

Study Summary

This study will evaluate the efficacy, safety, durability, and pharmacokinetics of faricimab administered at intervals as specified in the protocol, compared with aflibercept once every 8 weeks (Q8W), in participants with neovascular age-related macular degeneration (nAMD).

Conditions Studied

Interventions

  • PROCEDURE Sham Procedure
  • DRUG Faricimab
  • DRUG Aflibercept

Study Locations (20)

California

  • Retinal Diagnostic Center — Campbell
  • The Retina Partners — Encino
  • Jacobs Retina center at the Shiley eye Institute UCSD — La Jolla
  • South Coast Retina Center — Long Beach
  • Southern CA Desert Retina Cons — Palm Desert
  • California Eye Specialists Medical group Inc. — Pasadena
  • Retina Consultants, San Diego — Poway
  • Retina Consultants of Southern California — Redlands
  • University of California, Davis, Eye Center — Sacramento

Florida

  • Rand Eye — Deerfield Beach
  • Florida Eye Associates — Melbourne
  • Retina Specialty Institute — Pensacola
  • Fort Lauderdale Eye Institute — Plantation
  • Retina Vitreous Assoc of FL — St. Petersburg

Arizona

  • Retinal Research Institute, LLC — Phoenix
  • Barnet Dulaney Perkins Eye Center — Phoenix
  • Retina Associates Southwest PC — Tucson

Colorado

  • Retina Consultants of Southern — Colorado Springs

Connecticut

  • Retina Group of New England — New London

Illinois

  • Northwestern Medical Group/Northwestern University — Chicago

Trial Details

FieldValue
Enrollment Target 671 participants
Start Date 2019-02-19
Est. Completion 2022-01-18
Phase Phase 3

Sponsor

Hoffmann-La Roche

758 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03823287

The ClinicalTrials.gov registry entry for NCT03823287 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 671 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Wet Macular Degeneration appearing as the primary indexed condition, and to 3 interventions — of which Sham Procedure is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03823287 reports 20 study locations spanning 6 distinct geographic areas — top geographies include California, Florida, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03823287 about?

NCT03823287 is a clinical study titled "A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (TENAYA)". This study will evaluate the efficacy, safety, durability, and pharmacokinetics of faricimab administered at intervals as specified in the protocol, compared with aflibercept once every 8 weeks (Q8W), in participants with neovascular age-related macular degeneration (nAMD).

What is the current status of trial NCT03823287?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 671 participants. The study started on 2019-02-19. Estimated completion is 2022-01-18.

What conditions does trial NCT03823287 study?

This clinical trial studies the following conditions: Wet Macular Degeneration. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03823287?

The interventions under investigation include: Sham Procedure (PROCEDURE), Faricimab (DRUG), Aflibercept (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03823287?

This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03823287 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial