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COMPLETED Phase 3

A Study to Evaluate SHR-1210 in Combination With Apatinib as First-Line Therapy in Patients With Advanced HCC

NCT03764293 · View on ClinicalTrials.gov ↗

Study Summary

This is a randomized, open-label, international, multi-center, phase III trial to evaluate the efficacy and safety of SHR-1210 plus apatinib mesylate versus sorafenib as first-line therapy in patients with advanced HCC.

Interventions

  • DRUG Sorafenib
  • DRUG SHR-1210
  • DRUG Apatinib

Study Locations (20)

Other

  • Cliniques Universitaires de Bruxelles Hopital Erasme — Brussels
  • Cliniques Universitaires Saint-Luc — Brussels
  • UZA — Edegem
  • AZ Maria Middelares — Ghent
  • AZ Groeninge — Kortrijk

Anhui

  • Anhui Provincal Cancer Hospital — Hefei
  • Anhui Provincal Hospital — Hefei
  • The First Affiliated Hospital Of Anhui Medical University — Hefei
  • The Second Affiliated Hospital Of Anhui Medical University — Hefei

California

  • Beverly Hills Cancer Center — Beverly Hills
  • University of California San Diego (UCSD)-Moores Cancer Center — La Jolla
  • University of California - Irvine — Orange

Texas

  • The Center for Cancer and Blood Disorders — Fort Worth
  • MD Anderson Cancer Center — Houston
  • Renovatio Clinical — The Woodlands

Beijing Municipality

  • Chinese Academy of Medical Sciences Cancer Hospital — Beijing
  • Beijing cancer Hospital — Beijing
  • Peking University International Hospital — Beijing

Maryland

  • University of Maryland — Baltimore

New York

  • Cornell University Weill Cornell Medical College — New York

Trial Details

FieldValue
Enrollment Target 543 participants
Start Date 2019-06-10
Est. Completion 2023-06-14
Phase Phase 3

Sponsor

Jiangsu HengRui Medicine Co.

4 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03764293

The ClinicalTrials.gov registry entry for NCT03764293 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 543 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Jiangsu HengRui Medicine Co., which has 4 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Locally Advanced or Metastatic and Unresectable HCC appearing as the primary indexed condition, and to 3 interventions — of which Sorafenib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03764293 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Other, Anhui, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03764293 about?

NCT03764293 is a clinical study titled "A Study to Evaluate SHR-1210 in Combination With Apatinib as First-Line Therapy in Patients With Advanced HCC". This is a randomized, open-label, international, multi-center, phase III trial to evaluate the efficacy and safety of SHR-1210 plus apatinib mesylate versus sorafenib as first-line therapy in patients with advanced HCC.

What is the current status of trial NCT03764293?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 543 participants. The study started on 2019-06-10. Estimated completion is 2023-06-14.

What conditions does trial NCT03764293 study?

This clinical trial studies the following conditions: Locally Advanced or Metastatic and Unresectable HCC. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03764293?

The interventions under investigation include: Sorafenib (DRUG), SHR-1210 (DRUG), Apatinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03764293?

This trial is sponsored by Jiangsu HengRui Medicine Co., which has 4 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03764293 being conducted?

This trial has 20 study locations across California, Maryland, New York, Texas, Anhui. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial