Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Myeloma-Developing Regimens Using Genomics (MyDRUG)
NCT03732703 · View on ClinicalTrials.gov ↗
Study Summary
The MyDRUG study is a type of Precision Medicine trial to treat patients with drugs targeted to affect specific genes that are mutated as part of the disease. Mutations in genes can lead to uncontrolled cell growth and cancer. Patients with a greater than 25% mutation to any of the following genes; CDKN2C, FGFR3, KRAS, NRAS, BRAF V600E, IDH2 or T(11;14) can be enrolled to one of the treatment arms. These arms have treatments specifically directed to the mutated genes. Patients that do not have a greater than 25% mutation to the genes listed can be enrolled to a non-actionable treatment arm. The genetic sequencing of the patient's tumor is required via enrollment to the MMRF002 study: Clinical-grade Molecular Profiling of Patients with Multiple Myeloma and Related Plasma Cell Malignancies. (NCT02884102).
Conditions Studied
Interventions
- DRUG Abemaciclib, dexamethasone, ixazomib, pomalidomide
- DRUG Enasidenib, dexamethasone, ixazomib, pomalidomide
- DRUG Cobimetinib, dexamethasone, ixazomib, pomalidomide
- DRUG Erdafitinib, dexamethasone, ixazomib, pomalidomide
- DRUG Venetoclax, dexamethasone, ixazomib, pomalidomide
Study Locations (16)
Massachusetts
- Massachusetts General Hospital Cancer Center — Boston
- Beth Israel Deaconess — Boston
- Dana Farber Cancer Institute — Boston
Michigan
- University of Michigan Health System — Ann Arbor
- Karmanos Cancer Center — Detroit
New York
- Mount Sinai School of Medicine — New York
- Memorial Sloan Kettering Cancer Center — New York
Arizona
- Mayo Clinic - Arizona — Phoenix
California
- City of Hope — Duarte
Georgia
- Emory University — Atlanta
Minnesota
- Mayo Clinic - Minnesota — Rochester
Missouri
- Washington University School of Medicine Division of Medical Oncology — St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 103 participants |
| Start Date | 2019-04-01 |
| Est. Completion | 2024-12-31 |
| Phase | Phase 1 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03732703
The ClinicalTrials.gov registry entry for NCT03732703 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 103 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Multiple Myeloma Research Consortium, which has 30 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Relapsed Refractory Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions — of which Abemaciclib, dexamethasone, ixazomib, pomalidomide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03732703 reports 16 study locations spanning 12 distinct geographic areas — top geographies include Massachusetts, Michigan, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03732703 about?
NCT03732703 is a clinical study titled "Myeloma-Developing Regimens Using Genomics (MyDRUG)". The MyDRUG study is a type of Precision Medicine trial to treat patients with drugs targeted to affect specific genes that are mutated as part of the disease. Mutations in genes can lead to uncontrolled cell growth and cancer. Patients with a greater than 25% mutation to any of the following genes; ...
What is the current status of trial NCT03732703?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 103 participants. The study started on 2019-04-01. Estimated completion is 2024-12-31.
What conditions does trial NCT03732703 study?
This clinical trial studies the following conditions: Relapsed Refractory Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03732703?
The interventions under investigation include: Abemaciclib, dexamethasone, ixazomib, pomalidomide (DRUG), Enasidenib, dexamethasone, ixazomib, pomalidomide (DRUG), Cobimetinib, dexamethasone, ixazomib, pomalidomide (DRUG), Erdafitinib, dexamethasone, ixazomib, pomalidomide (DRUG), Venetoclax, dexamethasone, ixazomib, pomalidomide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03732703?
This trial is sponsored by Multiple Myeloma Research Consortium, which has 30 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03732703 being conducted?
This trial has 16 study locations across Arizona, California, Georgia, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.