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NCT03723226 · ClinicalTrials.gov registry record · NA
BFR and Muscle Mitochondrial Oxidative Capacity
A NA study of Hypertrophy and Strength, sponsored by Louisiana State University and A&M College.
- Completed
- Registry status
- NA
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT03723226 is a NA study of Hypertrophy and Strength that has completed, run by Louisiana State University and A&M College. The registered enrollment target is 24 participants, below the 32-participant average among 4 other Hypertrophy trials with a reported enrollment target (25% lower). The trial reports 1 study location across 1 state.
The verdict
NCT03723226, a NA study of Hypertrophy and Strength, has completed, sponsored by Louisiana State University and A&M College.
- COMPLETED
- Registry status
- NA
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
Blood flow restricted (BFR) exercise has been shown to improve skeletal muscle adaptations to resistance exercise. BFR uses blood pressure cuffs (i.e., tourniquets) to reduce skeletal muscle blood flow during resistance exercise. One benefit of BFR is that skeletal muscle adaptations to resistance exercise training including muscle hypertrophy and increases in strength can be achieved at lower-loads (e.g., 25-30% 1RM), that are often comparable to more traditional resistance training loads (70-85% 1RM). However, the impact that low-load BFR resistance exercise has on muscle quality and bioenergetics is unknown. The present study will examine the impact of 6 weeks of low-load, single-leg resistance exercise training with or without personalized BFR on measures of muscle mass, strength, quality, and mitochondrial bioenergetics. The investigators will recruit and study up to 30, previously sedentary, healthy, college-aged adults (18-40 years). The investigators will measure muscle mass using Dual Energy X-Ray Absorptiometry and muscle strength and endurance using isokinetic testing. The investigators will normalize knee extensor strength to lower limb lean mass to quantify muscle quality. The investigators will also use near infrared spectroscopy (NIRS) to measure mitochondrial oxidative capacity in the vastus lateralis. Finally, the investigators will measure markers of systemic inflammation and markers of muscle damage using commercially available ELISA assays.
Conditions Studied
Interventions
- BEHAVIORAL Low Load Resistance Exercise
- BEHAVIORAL Low Load Resistance Exercise + BFR
Study Locations (1)
Louisiana
- Lousiana State University - Baton Rouge
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2019-01-28 |
| Est. Completion | 2023-07-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03723226
The ClinicalTrials.gov registry entry for NCT03723226 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 32-participant average among 4 other Hypertrophy trials with a reported enrollment target (25% lower). The listed sponsor is Louisiana State University and A&M College, which has 7 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Hypertrophy appearing as the primary indexed condition, and to 2 interventions - of which Low Load Resistance Exercise is the first listed.
NCT03723226 reports 1 study location spanning 1 distinct geographic area - top geographies include Louisiana.
Frequently Asked Questions
What is clinical trial NCT03723226 about?
NCT03723226 is a clinical study titled "BFR and Muscle Mitochondrial Oxidative Capacity". Blood flow restricted (BFR) exercise has been shown to improve skeletal muscle adaptations to resistance exercise. BFR uses blood pressure cuffs (i.e., tourniquets) to reduce skeletal muscle blood flow during resistance exercise. One benefit of BFR is that skeletal muscle adaptations to resistance e...
What is the current status of trial NCT03723226?
This trial is currently completed. It is a NA study. The enrollment target is 24 participants. The study started on 2019-01-28. Estimated completion is 2023-07-01.
What conditions does trial NCT03723226 study?
This clinical trial studies the following conditions: Hypertrophy, Strength, Mitochondria.
What interventions are being tested in trial NCT03723226?
The interventions under investigation include: Low Load Resistance Exercise (BEHAVIORAL), Low Load Resistance Exercise + BFR (BEHAVIORAL).
Who is sponsoring clinical trial NCT03723226?
This trial is sponsored by Louisiana State University and A&M College, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03723226 being conducted?
This trial has 1 study location across Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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