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A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma
NCT03470922 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to determine whether relatlimab in combination with nivolumab is more effective than nivolumab monotherapy in treating unresectable melanoma or melanoma that has spread.
Conditions Studied
Interventions
- BIOLOGICAL Nivolumab
- BIOLOGICAL Relatlimab
Study Locations (20)
California
- Local Institution - 0020 — Los Angeles
- Coastal Integrative Cancer Care — San Luis Obispo
- Local Institution - 0116 — Santa Barbara
Florida
- Local Institution - 0013 — Jacksonville
- Local Institution - 0117 — Orlando
- Local Institution - 0007 — Tampa
Maryland
- Local Institution - 0077 — Baltimore
- Local Institution - 0120 — Baltimore
Massachusetts
- Local Institution - 0014 — Boston
- Local Institution - 0134 — Boston
Minnesota
- Local Institution - 0009 — Minneapolis
- Local Institution - 0011 — Rochester
Arizona
- Local Institution - 0010 — Tucson
District of Columbia
- Local Institution - 0012 — Washington D.C.
Georgia
- Local Institution - 0038 — Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 714 participants |
| Start Date | 2018-04-11 |
| Est. Completion | 2030-12-15 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03470922
The ClinicalTrials.gov registry entry for NCT03470922 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 714 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Bristol-Myers Squibb, which has 504 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Melanoma appearing as the primary indexed condition, and to 2 interventions — of which Nivolumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03470922 reports 20 study locations spanning 13 distinct geographic areas — top geographies include California, Florida, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03470922 about?
NCT03470922 is a clinical study titled "A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma". The purpose of this study is to determine whether relatlimab in combination with nivolumab is more effective than nivolumab monotherapy in treating unresectable melanoma or melanoma that has spread.
What is the current status of trial NCT03470922?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 714 participants. The study started on 2018-04-11. Estimated completion is 2030-12-15.
What conditions does trial NCT03470922 study?
This clinical trial studies the following conditions: Melanoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03470922?
The interventions under investigation include: Nivolumab (BIOLOGICAL), Relatlimab (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03470922?
This trial is sponsored by Bristol-Myers Squibb, which has 504 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03470922 being conducted?
This trial has 20 study locations across Arizona, California, District of Columbia, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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