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COMPLETED Phase 1

CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients With Sarcoma

NCT03425279 · View on ClinicalTrials.gov ↗

Study Summary

The objective of this study is to assess the safety and efficacy of mecbotamab vedotin (BA3011) in solid tumors.

Interventions

  • BIOLOGICAL PD-1 inhibitor
  • BIOLOGICAL CAB-AXL-ADC

Study Locations (20)

California

  • Children's Hospital Los Angeles — Los Angeles
  • USC Norris Comprehensive Cancer Center — Los Angeles
  • Tower Hematology Oncology Medical Group — Los Angeles
  • Precision NextGen Oncology — Los Angeles
  • UCSF Medical Center - Cancer Immunotherapy Clinic (CIC) — San Francisco

New York

  • Roswell Park Cancer Institute — Buffalo
  • Columbia University — New York
  • Memorial Sloan Kettering — New York

Colorado

  • University of Colorado — Aurora
  • Sarah Cannon Research Institute at Health One — Denver

Massachusetts

  • Massachusetts General Hospital — Boston
  • Dana-Farber Cancer Institute — Boston

Arizona

  • The University of Arizona Cancer Center — Tucson

District of Columbia

  • Children's Research Institute — Washington D.C.

Florida

  • Moffitt Cancer Center — Tampa

Illinois

  • Northwestern University — Chicago

Trial Details

FieldValue
Enrollment Target 245 participants
Start Date 2018-02-15
Est. Completion 2025-01-08
Phase Phase 1

Sponsor

BioAtla

4 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03425279

The ClinicalTrials.gov registry entry for NCT03425279 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 245 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BioAtla, which has 4 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Undifferentiated Pleomorphic Sarcoma appearing as the primary indexed condition, and to 2 interventions — of which PD-1 inhibitor is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03425279 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, New York, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03425279 about?

NCT03425279 is a clinical study titled "CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients With Sarcoma". The objective of this study is to assess the safety and efficacy of mecbotamab vedotin (BA3011) in solid tumors.

What is the current status of trial NCT03425279?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 245 participants. The study started on 2018-02-15. Estimated completion is 2025-01-08.

What conditions does trial NCT03425279 study?

This clinical trial studies the following conditions: Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03425279?

The interventions under investigation include: PD-1 inhibitor (BIOLOGICAL), CAB-AXL-ADC (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03425279?

This trial is sponsored by BioAtla, which has 4 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03425279 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial