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ACTIVE NOT RECRUITING Phase 1

Study Evaluating Safety and Efficacy of UCART123v1.2 in Patients With Relapsed/Refractory Acute Myeloid Leukemia

NCT03190278 · View on ClinicalTrials.gov ↗

Study Summary

Phase I, open-label, dose-escalation and dose-expansion study evaluating the safety and efficacy of Universal Chimeric Antigen Receptor T-cell (UCART) targeting the Cluster of Differentiation 123 (CD123) in patients with relapsed/refractory acute myeloid leukemia (AML). The purpose of this study is to evaluate the safety and clinical activity of Universal Chimeric Antigen Receptor T-cells targeting CD123 (UCART123v1.2) and determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D).

Interventions

  • BIOLOGICAL UCART123v1.2

Study Locations (8)

New York

  • Roswell Park Cancer Institute — Buffalo
  • Weill Medical College of Cornell University — New York

California

  • University of California, San Francisco (UCSF) - Helen Diller Family Comprehensive Cancer Center — San Francisco

Florida

  • H. Lee Moffitt Cancer Center & Research Institute — Tampa

Illinois

  • Northwestern University — Chicago

Massachusetts

  • Dana-Farber Cancer Institute — Boston

Pennsylvania

  • University of Pennsylvania - Abramson Cancer Center — Philadelphia

Texas

  • MD Anderson Cancer Center — Houston

Trial Details

FieldValue
Enrollment Target 29 participants
Start Date 2017-06-19
Est. Completion 2025-12
Phase Phase 1

Sponsor

Cellectis S.A.

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03190278

The ClinicalTrials.gov registry entry for NCT03190278 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 29 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Cellectis S.A., which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Relapsed/Refractory Acute Myeloid Leukemia appearing as the primary indexed condition, and to 1 intervention — of which UCART123v1.2 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03190278 reports 8 study locations spanning 7 distinct geographic areas — top geographies include New York, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03190278 about?

NCT03190278 is a clinical study titled "Study Evaluating Safety and Efficacy of UCART123v1.2 in Patients With Relapsed/Refractory Acute Myeloid Leukemia". Phase I, open-label, dose-escalation and dose-expansion study evaluating the safety and efficacy of Universal Chimeric Antigen Receptor T-cell (UCART) targeting the Cluster of Differentiation 123 (CD123) in patients with relapsed/refractory acute myeloid leukemia (AML). The purpose of this study is ...

What is the current status of trial NCT03190278?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 29 participants. The study started on 2017-06-19. Estimated completion is 2025-12.

What conditions does trial NCT03190278 study?

This clinical trial studies the following conditions: Relapsed/Refractory Acute Myeloid Leukemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03190278?

The interventions under investigation include: UCART123v1.2 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03190278?

This trial is sponsored by Cellectis S.A., which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03190278 being conducted?

This trial has 8 study locations across California, Florida, Illinois, Massachusetts, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial