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COMPLETED Phase 2

Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma

NCT03070392 · View on ClinicalTrials.gov ↗

Study Summary

To evaluate the overall survival of HLA-A\*0201 positive adult patients with previously untreated advanced UM receiving IMCgp100 compared to Investigator's Choice of dacarbazine, ipilimumab, or pembrolizumab.

Conditions Studied

Interventions

  • BIOLOGICAL Pembrolizumab
  • BIOLOGICAL Ipilimumab
  • DRUG Dacarbazine
  • BIOLOGICAL IMCgp100

Study Locations (20)

California

  • UCLA Medical Center — Los Angeles
  • The Angeles Clinic and Research Institute — Los Angeles
  • Byers Eye Institute, Stanford University — Palo Alto
  • California Pacific Medical Center — San Francisco

New York

  • Roswell Park Cancer Institute — Buffalo
  • Columbia University Medical Center — New York
  • Memorial Sloan Kettering Cancer Center — New York

Illinois

  • Northwestern University — Chicago
  • The University of Chicago Medicine — Chicago

Massachusetts

  • Massachusetts General Hospital — Boston
  • Dana Farber Cancer Institute — Boston

Colorado

  • University of Colorado — Aurora

Florida

  • University of Miami - Sylvester Comprehensive Cancer Center — Miami

Georgia

  • Winship Cancer Institute of Emory University — Atlanta

Iowa

  • University of Iowa — Iowa City

Trial Details

FieldValue
Enrollment Target 378 participants
Start Date 2017-10-16
Est. Completion 2025-09-17
Phase Phase 2

Sponsor

Immunocore

4 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03070392

The ClinicalTrials.gov registry entry for NCT03070392 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 378 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Immunocore, which has 4 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Uveal Melanoma appearing as the primary indexed condition, and to 4 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03070392 reports 20 study locations spanning 13 distinct geographic areas — top geographies include California, New York, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03070392 about?

NCT03070392 is a clinical study titled "Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma". To evaluate the overall survival of HLA-A\*0201 positive adult patients with previously untreated advanced UM receiving IMCgp100 compared to Investigator's Choice of dacarbazine, ipilimumab, or pembrolizumab.

What is the current status of trial NCT03070392?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 378 participants. The study started on 2017-10-16. Estimated completion is 2025-09-17.

What conditions does trial NCT03070392 study?

This clinical trial studies the following conditions: Uveal Melanoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03070392?

The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Ipilimumab (BIOLOGICAL), Dacarbazine (DRUG), IMCgp100 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03070392?

This trial is sponsored by Immunocore, which has 4 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03070392 being conducted?

This trial has 20 study locations across California, Colorado, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial