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COMPLETED Phase 3

A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-01)

NCT02932943 · View on ClinicalTrials.gov ↗

Study Summary

This study will evaluate the efficacy, safety, and tolerability of rapastinel 450 mg compared to placebo adjunctive to antidepressant therapy (ADT) in patients with major depressive disorder (MDD) who have a partial response to ADT.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Rapastinel

Study Locations (20)

California

  • Southern California Research LLC. — Beverly Hills
  • ATP Clinical Research Inc. — Costa Mesa
  • Pharmacology Research Institute — Encino
  • Collaborative Neuroscience Network, LLC — Garden Grove
  • Synergy San Diego — Lemon Grove
  • Pharmacology Research Institute — Los Alamitos
  • Excell Research — Oceanside
  • Anderson Clinical Research — Redlands
  • Thomas M. Shiovitz, M.D., Inc., DBA California Neuroscience Research Medical Group, Inc., — Sherman Oaks
  • Viking Clinical Research — Temecula
  • Pacific Clinical Research Medical — Upland

Florida

  • Meridien Research — Bradenton
  • MD Clinical — Hallandale
  • Clinical Neuroscience Solutions, Inc — Jacksonville
  • Meridien Research — Lakeland

Georgia

  • Institute for Advanced Medical Research — Alpharetta
  • Atlanta Center for Medical Research — Atlanta

Connecticut

  • Comprehensive Psychiatric Care — Norwich

Massachusetts

  • Adams Clinical Trials — Watertown

Nevada

  • Altea Research — Las Vegas

Trial Details

FieldValue
Enrollment Target 465 participants
Start Date 2016-10-15
Est. Completion 2018-11-08
Phase Phase 3

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02932943

The ClinicalTrials.gov registry entry for NCT02932943 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 465 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Naurex, Inc, an affiliate of Allergan, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Depressive Disorder, Major appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02932943 reports 20 study locations spanning 6 distinct geographic areas — top geographies include California, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02932943 about?

NCT02932943 is a clinical study titled "A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-01)". This study will evaluate the efficacy, safety, and tolerability of rapastinel 450 mg compared to placebo adjunctive to antidepressant therapy (ADT) in patients with major depressive disorder (MDD) who have a partial response to ADT.

What is the current status of trial NCT02932943?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 465 participants. The study started on 2016-10-15. Estimated completion is 2018-11-08.

What conditions does trial NCT02932943 study?

This clinical trial studies the following conditions: Depressive Disorder, Major. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02932943?

The interventions under investigation include: Placebo (DRUG), Rapastinel (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02932943?

This trial is sponsored by Naurex, Inc, an affiliate of Allergan, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02932943 being conducted?

This trial has 20 study locations across California, Connecticut, Florida, Georgia, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial